Daily Papers

Medical image foundation models (MIFMs) have demonstrated remarkable potential for a wide range of clinical tasks, yet their development is constrained by the scarcity, heterogeneity, and high cost of large-scale annotated datasets. Here, we propose RaSD (Randomized Synthesis and Disentanglement), a scalable framework for pre-training MIFMs entirely on synthetic data. By modeling anatomical structures and appearance variations with randomized Gaussian distributions, RaSD exposes models to sufficient multi-scale structural and appearance perturbations, forcing them to rely on invariant and task-relevant anatomical cues rather than dataset-specific textures, thereby enabling robust and transferable representation learning. We pre-trained RaSD on 1.2 million 3D volumes and 9.6 million 2D images, and extensively evaluated the resulting models across 6 imaging modalities, 48 datasets, and 56 downstream tasks. Across all evaluated downstream tasks, RaSD consistently outperforms training-from-scratch models, achieves the best performance on 17 tasks, and remains comparable to models pre-trained on large real datasets in most others. These results demonstrate that the capacity of synthetic data alone to drive robust representation learning. Our findings establish a paradigm shift in medical AI, demonstrating that synthetic data can serve as a "free lunch" for scalable, privacy-preserving, and clinically generalizable foundation models.

Traditional AI methods often rely on task-specific model designs and training, which constrain both the scalability of model size and generalization across different tasks. Here, we introduce ChemFM, a large foundation model specifically developed for chemicals. By conducting a series of scaling experiments, we identify UniChem as the informative molecular database for pre-training the foundation model. ChemFM comprises 3 billion parameters and is pre-trained on 178 million molecules using self-supervised causal language modeling to extract generalizable molecular representations. This model can be adapted to diverse downstream chemical applications using either full-parameter or parameter-efficient fine-tuning methods. ChemFM consistently outperforms state-of-the-art task-specific AI models across all tested tasks. Notably, it achieves up to 67.48% performance improvement across 34 property prediction benchmarks, up to 33.80% reduction in mean average deviation between conditioned and actual properties of generated molecules in conditional molecular generation tasks, and up to 3.7% top-1 accuracy improvement across 4 reaction prediction datasets. Moreover, ChemFM demonstrates its superior performance in predicting antibiotic activity and cytotoxicity, highlighting its potential to advance the discovery of novel antibiotics. Furthermore, we demonstrate that, as a foundation model, ChemFM exhibits strong data efficiency, requiring significantly fewer labeled training samples to achieve state-of-the-art performance. We anticipate that ChemFM will significantly advance chemistry research by providing a foundation model capable of effectively generalizing across a broad range of tasks with minimal additional training.

While computer science has seen remarkable advancements in foundation models, which remain underexplored in geoscience. Addressing this gap, we introduce a workflow to develop geophysical foundation models, including data preparation, model pre-training, and adaption to downstream tasks. From 192 globally collected 3-D seismic volumes, we create a carefully curated dataset of 2,286,422 2-D seismic images. Fully using these unlabeled images, we employ the self-supervised learning to pre-train a Transformer-based Seismic Foundation Model (SFM) for producing all-purpose seismic features that work across various tasks and surveys. Through experiments on seismic facies classification, geobody identification, interpolation, denoising, and inversion, our pre-trained model demonstrates versatility, generalization, scalability, and superior performance over baseline models. Conclusively, we provide a foundation model and vast dataset to advance AI in geophysics, addressing challenges (poor generalization, lacking labels, and repetitive training for task-specified models) of applying AI in geophysics and paving the way for future innovations in geoscience.

The field of computer vision is undergoing a paradigm shift toward large-scale foundation model pre-training via self-supervised learning (SSL). Leveraging large volumes of unlabeled brain MRI data, such models can learn anatomical priors that improve few-shot performance in diverse neuroimaging tasks. However, most SSL frameworks are tailored to natural images, and their adaptation to capture multi-modal MRI information remains underexplored. This work proposes a modality-invariant representation learning setup and evaluates its effectiveness in stroke and epilepsy lesion segmentation, following large-scale pre-training. Experimental results suggest that despite successful cross-modality alignment, lesion segmentation primarily benefits from preserving fine-grained modality-specific features. Model checkpoints and code are made publicly available.

We introduce GameGen-X, the first diffusion transformer model specifically designed for both generating and interactively controlling open-world game videos. This model facilitates high-quality, open-domain generation by simulating an extensive array of game engine features, such as innovative characters, dynamic environments, complex actions, and diverse events. Additionally, it provides interactive controllability, predicting and altering future content based on the current clip, thus allowing for gameplay simulation. To realize this vision, we first collected and built an Open-World Video Game Dataset from scratch. It is the first and largest dataset for open-world game video generation and control, which comprises over a million diverse gameplay video clips sampling from over 150 games with informative captions from GPT-4o. GameGen-X undergoes a two-stage training process, consisting of foundation model pre-training and instruction tuning. Firstly, the model was pre-trained via text-to-video generation and video continuation, endowing it with the capability for long-sequence, high-quality open-domain game video generation. Further, to achieve interactive controllability, we designed InstructNet to incorporate game-related multi-modal control signal experts. This allows the model to adjust latent representations based on user inputs, unifying character interaction and scene content control for the first time in video generation. During instruction tuning, only the InstructNet is updated while the pre-trained foundation model is frozen, enabling the integration of interactive controllability without loss of diversity and quality of generated video content.

This position and survey paper identifies the emerging convergence of neuroscience, artificial general intelligence (AGI), and neuromorphic computing toward a unified research paradigm. Using a framework grounded in brain physiology, we highlight how synaptic plasticity, sparse spike-based communication, and multimodal association provide design principles for next-generation AGI systems that potentially combine both human and machine intelligences. The review traces this evolution from early connectionist models to state-of-the-art large language models, demonstrating how key innovations like transformer attention, foundation-model pre-training, and multi-agent architectures mirror neurobiological processes like cortical mechanisms, working memory, and episodic consolidation. We then discuss emerging physical substrates capable of breaking the von Neumann bottleneck to achieve brain-scale efficiency in silicon: memristive crossbars, in-memory compute arrays, and emerging quantum and photonic devices. There are four critical challenges at this intersection: 1) integrating spiking dynamics with foundation models, 2) maintaining lifelong plasticity without catastrophic forgetting, 3) unifying language with sensorimotor learning in embodied agents, and 4) enforcing ethical safeguards in advanced neuromorphic autonomous systems. This combined perspective across neuroscience, computation, and hardware offers an integrative agenda for in each of these fields.

With the rise of powerful foundation models, a pre-training-fine-tuning paradigm becomes increasingly popular these days: A foundation model is pre-trained using a huge amount of data from various sources, and then the downstream users only need to fine-tune and adapt it to specific downstream tasks. However, due to the high computation complexity of adversarial training, it is not feasible to fine-tune the foundation model to improve its robustness on the downstream task. Observing the above challenge, we want to improve the downstream robustness without updating/accessing the weights in the foundation model. Inspired from existing literature in robustness inheritance (Kim et al., 2020), through theoretical investigation, we identify a close relationship between robust contrastive learning with the adversarial robustness of supervised learning. To further validate and utilize this theoretical insight, we design a simple-yet-effective robust auto-encoder as a data pre-processing method before feeding the data into the foundation model. The proposed approach has zero access to the foundation model when training the robust auto-encoder. Extensive experiments demonstrate the effectiveness of the proposed method in improving the robustness of downstream tasks, verifying the connection between the feature robustness (implied by small adversarial contrastive loss) and the robustness of the downstream task.

Clinical trials are fundamental in developing new drugs, medical devices, and treatments. However, they are often time-consuming and have low success rates. Although there have been initial attempts to create large language models (LLMs) for clinical trial design and patient-trial matching, these models remain task-specific and not adaptable to diverse clinical trial tasks. To address this challenge, we propose a clinical trial foundation model named Panacea, designed to handle multiple tasks, including trial search, trial summarization, trial design, and patient-trial matching. We also assemble a large-scale dataset, named TrialAlign, of 793,279 trial documents and 1,113,207 trial-related scientific papers, to infuse clinical knowledge into the model by pre-training. We further curate TrialInstruct, which has 200,866 of instruction data for fine-tuning. These resources enable Panacea to be widely applicable for a range of clinical trial tasks based on user requirements. We evaluated Panacea on a new benchmark, named TrialPanorama, which covers eight clinical trial tasks. Our method performed the best on seven of the eight tasks compared to six cutting-edge generic or medicine-specific LLMs. Specifically, Panacea showed great potential to collaborate with human experts in crafting the design of eligibility criteria, study arms, and outcome measures, in multi-round conversations. In addition, Panacea achieved 14.42% improvement in patient-trial matching, 41.78% to 52.02% improvement in trial search, and consistently ranked at the top for five aspects of trial summarization. Our approach demonstrates the effectiveness of Panacea in clinical trials and establishes a comprehensive resource, including training data, model, and benchmark, for developing clinical trial foundation models, paving the path for AI-based clinical trial development.

Recent studies have indicated that vision models pre-trained on images can serve as time series foundation models (TSFMs) by reformulating time series forecasting (TSF) as image reconstruction. However, effective cross-modal transfer from vision to time series remains challenging due to three discrepancies: (1) the data-modality gap between structured, bounded image data and unbounded, heterogeneous time series; (2) the multivariate-forecasting gap between fixed RGB-three-channel vision models and time series with arbitrary numbers of variates; and (3) the probabilistic-forecasting gap between the deterministic outputs of vision models and the requirement for uncertainty-aware probabilistic predictions. To bridge these gaps, we propose VisonTS++, a TSFM based on continual pre-training of a vision model on large-scale time series. Our approach introduces three key innovations: (1) vision-model-based filtering to identify high-quality sequences to stabilize pre-training and mitigate modality gap; (2) colorized multivariate conversion, encoding multivariate series as multi-subfigure RGB images to enhance cross-variate modeling; (3) multi-quantile forecasting, using parallel reconstruction heads to generate quantile forecasts without parametric assumptions. Experiments show that VisionTS++ achieves state-of-the-art performance in both in-distribution and out-of-distribution forecasting, outperforming specialized TSFMs by 6%-44% in MSE reduction and ranking first in GIFT-Eval benchmark which comprises 23 datasets across 7 domains. Our work demonstrates that with appropriate adaptation, vision models can effectively generalize to TSF, thus advancing the pursuit of universal TSFMs. Code is available at https://github.com/HALF111/VisionTSpp.

In recent years, a plethora of open-source foundation models have emerged, achieving remarkable progress in some widely attended fields, with performance being quite close to that of closed-source models. However, in high-value but more challenging scientific professional fields, either the fields still rely on expert models, or the progress of general foundation models lags significantly compared to those in popular areas, far from sufficient for transforming scientific research and leaving substantial gap between open-source models and closed-source models in these scientific domains. To mitigate this gap and explore a step further toward Artificial General Intelligence (AGI), we introduce Intern-S1, a specialized generalist equipped with general understanding and reasoning capabilities with expertise to analyze multiple science modal data. Intern-S1 is a multimodal Mixture-of-Experts (MoE) model with 28 billion activated parameters and 241 billion total parameters, continually pre-trained on 5T tokens, including over 2.5T tokens from scientific domains. In the post-training stage, Intern-S1 undergoes offline and then online reinforcement learning (RL) in InternBootCamp, where we propose Mixture-of-Rewards (MoR) to synergize the RL training on more than 1000 tasks simultaneously. Through integrated innovations in algorithms, data, and training systems, Intern-S1 achieved top-tier performance in online RL training.On comprehensive evaluation benchmarks, Intern-S1 demonstrates competitive performance on general reasoning tasks among open-source models and significantly outperforms open-source models in scientific domains, surpassing closed-source state-of-the-art models in professional tasks, such as molecular synthesis planning, reaction condition prediction, predicting thermodynamic stabilities for crystals. Our models are available at https://huggingface.co/internlm/Intern-S1.

In contrast to numerous NLP and 2D vision foundational models, learning a 3D foundational model poses considerably greater challenges. This is primarily due to the inherent data variability and diversity of downstream tasks. In this paper, we introduce a novel universal 3D pre-training framework designed to facilitate the acquisition of efficient 3D representation, thereby establishing a pathway to 3D foundational models. Considering that informative 3D features should encode rich geometry and appearance cues that can be utilized to render realistic images, we propose to learn 3D representations by differentiable neural rendering. We train a 3D backbone with a devised volumetric neural renderer by comparing the rendered with the real images. Notably, our approach seamlessly integrates the learned 3D encoder into various downstream tasks. These tasks encompass not only high-level challenges such as 3D detection and segmentation but also low-level objectives like 3D reconstruction and image synthesis, spanning both indoor and outdoor scenarios. Besides, we also illustrate the capability of pre-training a 2D backbone using the proposed methodology, surpassing conventional pre-training methods by a large margin. For the first time, PonderV2 achieves state-of-the-art performance on 11 indoor and outdoor benchmarks, implying its effectiveness. Code and models are available at https://github.com/OpenGVLab/PonderV2.

We introduce Metis, a foundation model for unified speech generation. Unlike previous task-specific or multi-task models, Metis follows a pre-training and fine-tuning paradigm. It is pre-trained on large-scale unlabeled speech data using masked generative modeling and then fine-tuned to adapt to diverse speech generation tasks. Specifically, 1) Metis utilizes two discrete speech representations: SSL tokens derived from speech self-supervised learning (SSL) features, and acoustic tokens directly quantized from waveforms. 2) Metis performs masked generative pre-training on SSL tokens, utilizing 300K hours of diverse speech data, without any additional condition. 3) Through fine-tuning with task-specific conditions, Metis achieves efficient adaptation to various speech generation tasks while supporting multimodal input, even when using limited data and trainable parameters. Experiments demonstrate that Metis can serve as a foundation model for unified speech generation: Metis outperforms state-of-the-art task-specific or multi-task systems across five speech generation tasks, including zero-shot text-to-speech, voice conversion, target speaker extraction, speech enhancement, and lip-to-speech, even with fewer than 20M trainable parameters or 300 times less training data. Audio samples are are available at https://metis-demo.github.io/.

Graphs are able to model interconnected entities in many online services, supporting a wide range of applications on the Web. This raises an important question: How can we train a graph foundational model on multiple source domains and adapt to an unseen target domain? A major obstacle is that graphs from different domains often exhibit divergent characteristics. Some studies leverage large language models to align multiple domains based on textual descriptions associated with the graphs, limiting their applicability to text-attributed graphs. For text-free graphs, a few recent works attempt to align different feature distributions across domains, while generally neglecting structural differences. In this work, we propose a novel Structure Alignment framework for text-free Multi-domain Graph Pre-Training and cross-domain adaptation (SAMGPT). It is designed to learn multi-domain knowledge from graphs originating in multiple source domains, which can then be adapted to address applications in an unseen target domain. Specifically, we introduce a set of structure tokens to harmonize structure-based aggregation across source domains during the pre-training phase. Next, for cross-domain adaptation, we design dual prompts, namely, holistic prompts and specific prompts, which adapt unified multi-domain structural knowledge and fine-grained, domain-specific information, respectively, to a target domain. Finally, we conduct comprehensive experiments on seven public datasets to evaluate and analyze the effectiveness of SAMGPT.

Objective: To enable continuous, long-term neuro-monitoring on wearable devices by overcoming the computational bottlenecks of Transformer-based Electroencephalography (EEG) foundation models and the quantization challenges inherent to State-Space Models (SSMs). Methods: We present FEMBA, a bidirectional Mamba architecture pre-trained on over 21,000 hours of EEG. We introduce a novel Physiologically-Aware pre-training objective, consisting of a reconstruction with low-pass filtering, to prioritize neural oscillations over high-frequency artifacts. To address the activation outliers common in SSMs, we employ Quantization-Aware Training (QAT) to compress the model to 2-bit weights. The framework is deployed on a parallel ultra-low-power RISC-V microcontroller (GAP9) using a custom double-buffered memory streaming scheme. Results: The proposed low-pass pre-training improves downstream AUROC on TUAB from 0.863 to 0.893 and AUPR from 0.862 to 0.898 compared to the best contrastive baseline. QAT successfully compresses weights with negligible performance loss, whereas standard post-training quantization degrades accuracy by approximately 30\%. The embedded implementation achieves deterministic real-time inference (1.70~s per 5~s window) and reduces the memory footprint by 74\% (to approx2~MB), achieving competitive accuracy with up to 27times fewer FLOPs than Transformer benchmarks. Conclusion: FEMBA demonstrates that Mamba-based foundation models can be effectively quantized and deployed on extreme-edge hardware without sacrificing the representation quality required for robust clinical analysis. Significance: This work establishes the first full-stack framework for deploying large-scale EEG foundation models on ultra-low-power wearables, facilitating continuous, SSM based monitoring for epilepsy and sleep disorders.

Polysomnography (PSG) provides the gold standard for sleep assessment but suffers from substantial heterogeneity across recording devices and cohorts. There have been growing efforts to build general-purpose foundation models (FMs) for sleep physiology, but lack an in-depth understanding of the pre-training process and scaling patterns that lead to more generalizable sleep FMs. To fill this gap, we curate a massive corpus of 166,500 hours of sleep recordings from nine public sources and establish SleepBench, a comprehensive, fully open-source benchmark. Leveraging SleepBench, we systematically evaluate four families of self-supervised pre-training objectives and uncover three critical findings: (1) existing FMs fail to generalize to missing channels at inference; (2) channel-invariant feature learning is essential for pre-training; and (3) scaling sample size, model capacity, and multi-source data mixture consistently improves downstream performance.With an enhanced pre-training and scaling recipe, we introduce OSF, a family of sleep FMs that achieves state-of-the-art performance across nine datasets on diverse sleep and disease prediction tasks. Further analysis of OSF also reveals intriguing properties in sample efficiency, hierarchical aggregation, and cross-dataset scaling.

Large foundation models have become central to modern machine learning, with performance scaling predictably with model size and data. However, training and deploying such models incur substantial computational and memory costs, motivating the development of low-precision training techniques. Recent work has demonstrated that 4-bit floating-point (FP4) formats--such as MXFP4 and NVFP4--can be successfully applied to linear GEMM operations in large language models (LLMs), achieving up to 4x improvements in compute throughput and memory efficiency compared to higher-precision baselines. In this work, we investigate the recently proposed HiFloat4 FP4 format for Huawei Ascend NPUs and systematically compare it with MXFP4 in large-scale training settings. All experiments are conducted on Ascend NPU clusters, with linear and expert GEMM operations performed entirely in FP4 precision. We evaluate both dense architectures (e.g., Pangu and LLaMA-style models) and mixture-of-experts (MoE) models, where both standard linear layers and expert-specific GEMMs operate in FP4. Furthermore, we explore stabilization techniques tailored to FP4 training that significantly reduce numerical degradation, maintaining relative error within 1% of full-precision baselines while preserving the efficiency benefits of 4-bit computation. Our results provide a comprehensive empirical study of FP4 training on NPUs and highlight the practical trade-offs between FP4 formats in large-scale dense and MoE models.

Video foundation models achieve strong performance across many video understanding tasks, but typically require large-scale pre-training on massive video datasets, resulting in substantial data and compute costs. In contrast, modern image foundation models already provide powerful spatial representations. This raises an important question: can competitive video models be built by reusing these spatial representations and pre-training only for temporal reasoning? We take initial steps toward exploring a lightweight training paradigm that freezes a pre-trained image foundation model and trains only a recurrent temporal module to process streaming video. By reusing an image foundation model as a spatial encoder, this approach could significantly reduce the amount of video data and compute required compared to end-to-end video pre-training. In this work, we explore the feasibility of this approach before investing in computing for video pre-training. Our empirical findings across multiple video understanding tasks suggest that strong temporal performance can emerge without large-scale video pre-training, motivating future work on recurrent video foundation models obtained by pre-training a temporal module on top of a frozen image foundation model. Code: https://github.com/tue-mps/towards-video-image-frozen .

In this paper, we present Chain-of-Models Pre-Training (CoM-PT), a novel performance-lossless training acceleration method for vision foundation models (VFMs). This approach fundamentally differs from existing acceleration methods in its core motivation: rather than optimizing each model individually, CoM-PT is designed to accelerate the training pipeline at the model family level, scaling efficiently as the model family expands. Specifically, CoM-PT establishes a pre-training sequence for the model family, arranged in ascending order of model size, called model chain. In this chain, only the smallest model undergoes standard individual pre-training, while the other models are efficiently trained through sequential inverse knowledge transfer from their smaller predecessors by jointly reusing the knowledge in the parameter space and the feature space. As a result, CoM-PT enables all models to achieve performance that is mostly superior to standard individual training while significantly reducing training cost, and this is extensively validated across 45 datasets spanning zero-shot and fine-tuning tasks. Notably, its efficient scaling property yields a remarkable phenomenon: training more models even results in higher efficiency. For instance, when pre-training on CC3M: i) given ViT-L as the largest model, progressively prepending smaller models to the model chain reduces computational complexity by up to 72%; ii) within a fixed model size range, as the VFM family scales across 3, 4, and 7 models, the acceleration ratio of CoM-PT exhibits a striking leap: from 4.13X to 5.68X and 7.09X. Since CoM-PT is naturally agnostic to specific pre-training paradigms, we open-source the code to spur further extensions in more computationally intensive scenarios, such as large language model pre-training.

Table foundation models bring high hopes to data science: pre-trained on tabular data to embark knowledge or priors, they should facilitate downstream tasks on tables. One specific challenge is that of data semantics: numerical entries take their meaning from context, e.g., column name. Pre-trained neural networks that jointly model column names and table entries have recently boosted prediction accuracy. While these models outline the promises of world knowledge to interpret table values, they lack the convenience of popular foundation models in text or vision. Indeed, they must be fine-tuned to bring benefits, come with sizeable computation costs, and cannot easily be reused or combined with other architectures. Here we introduce TARTE, a foundation model that transforms tables to knowledge-enhanced vector representations using the string to capture semantics. Pre-trained on large relational data, TARTE yields representations that facilitate subsequent learning with little additional cost. These representations can be fine-tuned or combined with other learners, giving models that push the state-of-the-art prediction performance and improve the prediction/computation performance trade-off. Specialized to a task or a domain, TARTE gives domain-specific representations that facilitate further learning. Our study demonstrates an effective approach to knowledge pre-training for tabular learning.

Foundation models are emerging as a powerful paradigm for fMRI analysis, but current approaches face a dual bottleneck of data- and training-efficiency. Atlas-based methods aggregate voxel signals into fixed regions of interest, reducing data dimensionality but discarding fine-grained spatial details, and requiring extremely large cohorts to train effectively as general-purpose foundation models. Atlas-free methods, on the other hand, operate directly on voxel-level information - preserving spatial fidelity but are prohibitively memory- and compute-intensive, making large-scale pre-training infeasible. We introduce SLIM-Brain (Sample-efficient, Low-memory fMRI Foundation Model for Human Brain), a new atlas-free foundation model that simultaneously improves both data- and training-efficiency. SLIM-Brain adopts a two-stage adaptive design: (i) a lightweight temporal extractor captures global context across full sequences and ranks data windows by saliency, and (ii) a 4D hierarchical encoder (Hiera-JEPA) learns fine-grained voxel-level representations only from the top-k selected windows, while deleting about 70% masked patches. Extensive experiments across seven public benchmarks show that SLIM-Brain establishes new state-of-the-art performance on diverse tasks, while requiring only 4 thousand pre-training sessions and approximately 30% of GPU memory comparing to traditional voxel-level methods.

The rapidly increasing computational cost of pretraining Large Language Models necessitates more efficient approaches. Numerous computational costs have been invested in existing well-trained checkpoints, but many of them remain underutilized due to engineering constraints or limited model capacity. To efficiently reuse this "sunk" cost, we propose to recycle pretrained checkpoints by expanding their parameter counts and continuing training. We propose orthogonal growth method well-suited for converged Mixture-of-Experts model: interpositional layer copying for depth growth and expert duplication with injected noise for width growth. To determine the optimal timing for such growth across checkpoints sequences, we perform comprehensive scaling experiments revealing that the final accuracy has a strong positive correlation with the amount of sunk cost, indicating that greater prior investment leads to better performance. We scale our approach to models with 70B parameters and over 1T training tokens, achieving 10.66% accuracy gain over training from scratch under the same additional compute budget. Our checkpoint recycling approach establishes a foundation for economically efficient large language model pretraining.

Self-Supervised Learning (SSL) is at the core of training modern large machine learning models, providing a scheme for learning powerful representations that can be used in a variety of downstream tasks. However, SSL strategies must be adapted to the type of training data and downstream tasks required. We propose RS3L ("Re-simulation-based self-supervised representation learning"), a novel simulation-based SSL strategy that employs a method of re-simulation to drive data augmentation for contrastive learning in the physical sciences, particularly, in fields that rely on stochastic simulators. By intervening in the middle of the simulation process and re-running simulation components downstream of the intervention, we generate multiple realizations of an event, thus producing a set of augmentations covering all physics-driven variations available in the simulator. Using experiments from high-energy physics, we explore how this strategy may enable the development of a foundation model; we show how RS3L pre-training enables powerful performance in downstream tasks such as discrimination of a variety of objects and uncertainty mitigation. In addition to our results, we make the RS3L dataset publicly available for further studies on how to improve SSL strategies.

This paper introduces SBAN (Source code, Binary, Assembly, and Natural Language Description), a large-scale, multi-dimensional dataset designed to advance the pre-training and evaluation of large language models (LLMs) for software code analysis. SBAN comprises more than 3 million samples, including 2.9 million benign and 672,000 malware respectively, each represented across four complementary layers: binary code, assembly instructions, natural language descriptions, and source code. This unique multimodal structure enables research on cross-representation learning, semantic understanding of software, and automated malware detection. Beyond security applications, SBAN supports broader tasks such as code translation, code explanation, and other software mining tasks involving heterogeneous data. It is particularly suited for scalable training of deep models, including transformers and other LLM architectures. By bridging low-level machine representations and high-level human semantics, SBAN provides a robust foundation for building intelligent systems that reason about code. We believe that this dataset opens new opportunities for mining software behavior, improving security analytics, and enhancing LLM capabilities in pre-training and fine-tuning tasks for software code mining.

Vision foundation models (VFMs) are pre-trained on extensive image datasets to learn general representations for diverse types of data. These models can subsequently be fine-tuned for specific downstream tasks, significantly boosting performance across a broad range of applications. However, existing vision foundation models that claim to be applicable to various clinical tasks are mostly pre-trained on 3D computed tomography (CT), which benefits from the availability of extensive 3D CT databases. Significant differences between CT and magnetic resonance imaging (MRI) in imaging principles, signal characteristics, and data distribution may hinder their practical performance and versatility in MRI-specific applications. Here, we propose Triad, a vision foundation model for 3D MRI. Triad adopts a widely used autoencoder architecture to learn robust representations from 131,170 3D MRI volumes and uses organ-independent imaging descriptions to constrain the semantic distribution of the visual modality. The above pre-training dataset is called Triad-131K, which is currently the largest 3D MRI pre-training dataset. We evaluate Triad across three tasks, namely, organ/tumor segmentation, organ/cancer classification, and medical image registration, in two data modalities (within-domain and out-of-domain) settings using 25 downstream datasets. By initializing models with Triad's pre-trained weights, nnUNet-Triad improves segmentation performance by 2.51% compared to nnUNet-Scratch across 17 datasets. Swin-B-Triad achieves a 3.97% improvement over Swin-B-Scratch in classification tasks across five datasets. SwinUNETR-Triad improves by 4.00% compared to SwinUNETR-Scratch in registration tasks across two datasets. Our study demonstrates that pre-training can improve performance when the data modalities and organs of upstream and downstream tasks are consistent.

Building general-purpose embodied agents across diverse hardware remains a central challenge in robotics, often framed as the ''one-brain, many-forms'' paradigm. Progress is hindered by fragmented data, inconsistent representations, and misaligned training objectives. We present ABot-M0, a framework that builds a systematic data curation pipeline while jointly optimizing model architecture and training strategies, enabling end-to-end transformation of heterogeneous raw data into unified, efficient representations. From six public datasets, we clean, standardize, and balance samples to construct UniACT-dataset, a large-scale dataset with over 6 million trajectories and 9,500 hours of data, covering diverse robot morphologies and task scenarios. Unified pre-training improves knowledge transfer and generalization across platforms and tasks, supporting general-purpose embodied intelligence. To improve action prediction efficiency and stability, we propose the Action Manifold Hypothesis: effective robot actions lie not in the full high-dimensional space but on a low-dimensional, smooth manifold governed by physical laws and task constraints. Based on this, we introduce Action Manifold Learning (AML), which uses a DiT backbone to predict clean, continuous action sequences directly. This shifts learning from denoising to projection onto feasible manifolds, improving decoding speed and policy stability. ABot-M0 supports modular perception via a dual-stream mechanism that integrates VLM semantics with geometric priors and multi-view inputs from plug-and-play 3D modules such as VGGT and Qwen-Image-Edit, enhancing spatial understanding without modifying the backbone and mitigating standard VLM limitations in 3D reasoning. Experiments show components operate independently with additive benefits. We will release all code and pipelines for reproducibility and future research.

Cytology is essential for cancer diagnostics and screening due to its minimally invasive nature. However, the development of robust deep learning models for digital cytology is challenging due to the heterogeneity in staining and preparation methods of samples, differences across organs, and the limited availability of large, diverse, annotated datasets. Developing a task-specific model for every cytology application is impractical and non-cytology-specific foundation models struggle to generalize to tasks in this domain where the emphasis is on cell morphology. To address these challenges, we introduce CytoFM, the first cytology self-supervised foundation model. Using iBOT, a self-supervised Vision Transformer (ViT) training framework incorporating masked image modeling and self-distillation, we pretrain CytoFM on a diverse collection of cytology datasets to learn robust, transferable representations. We evaluate CytoFM on multiple downstream cytology tasks, including breast cancer classification and cell type identification, using an attention-based multiple instance learning framework. Our results demonstrate that CytoFM performs better on two out of three downstream tasks than existing foundation models pretrained on histopathology (UNI) or natural images (iBOT-Imagenet). Visualizations of learned representations demonstrate our model is able to attend to cytologically relevant features. Despite a small pre-training dataset, CytoFM's promising results highlight the ability of task-agnostic pre-training approaches to learn robust and generalizable features from cytology data.

With abundant, unlabeled real faces, how can we learn robust and transferable facial representations to boost generalization across various face security tasks? We make the first attempt and propose FS-VFM, a scalable self-supervised pre-training framework, to learn fundamental representations of real face images. We introduce three learning objectives, namely 3C, that synergize masked image modeling (MIM) and instance discrimination (ID), empowering FS-VFM to encode both local patterns and global semantics of real faces. Specifically, we formulate various facial masking strategies for MIM and devise a simple yet effective CRFR-P masking, which explicitly prompts the model to pursue meaningful intra-region Consistency and challenging inter-region Coherency. We present a reliable self-distillation mechanism that seamlessly couples MIM with ID to establish underlying local-to-global Correspondence. After pre-training, vanilla vision transformers (ViTs) serve as universal Vision Foundation Models for downstream Face Security tasks: cross-dataset deepfake detection, cross-domain face anti-spoofing, and unseen diffusion facial forensics. To efficiently transfer the pre-trained FS-VFM, we further propose FS-Adapter, a lightweight plug-and-play bottleneck atop the frozen backbone with a novel real-anchor contrastive objective. Extensive experiments on 11 public benchmarks demonstrate that our FS-VFM consistently generalizes better than diverse VFMs, spanning natural and facial domains, fully, weakly, and self-supervised paradigms, small, base, and large ViT scales, and even outperforms SOTA task-specific methods, while FS-Adapter offers an excellent efficiency-performance trade-off. The code and models are available on https://fsfm-3c.github.io/fsvfm.html.

Satellite image time series (SITS) provide continuous observations of the Earth's surface, making them essential for applications such as environmental management and disaster assessment. However, existing spatiotemporal foundation models rely on plain vision transformers, which encode entire temporal sequences without explicitly capturing multiscale spatiotemporal relationships between land objects. This limitation hinders their effectiveness in downstream tasks. To overcome this challenge, we propose TiMo, a novel hierarchical vision transformer foundation model tailored for SITS analysis. At its core, we introduce a spatiotemporal gyroscope attention mechanism that dynamically captures evolving multiscale patterns across both time and space. For pre-training, we curate MillionST, a large-scale dataset of one million images from 100,000 geographic locations, each captured across 10 temporal phases over five years, encompassing diverse geospatial changes and seasonal variations. Leveraging this dataset, we adapt masked image modeling to pre-train TiMo, enabling it to effectively learn and encode generalizable spatiotemporal representations.Extensive experiments across multiple spatiotemporal tasks-including deforestation monitoring, land cover segmentation, crop type classification, and flood detection-demonstrate TiMo's superiority over state-of-the-art methods. Code, model, and dataset will be released at https://github.com/MiliLab/TiMo.

Foundation models have revolutionized language modeling, while whether this success is replicated in scientific computing remains unexplored. We present OmniArch, the first prototype aiming at solving multi-scale and multi-physics scientific computing problems with physical alignment. We addressed all three challenges with one unified architecture. Its pre-training stage contains a Fourier Encoder-decoder fading out the disharmony across separated dimensions and a Transformer backbone integrating quantities through temporal dynamics, and the novel PDE-Aligner performs physics-informed fine-tuning under flexible conditions. As far as we know, we first conduct 1D-2D-3D united pre-training on the PDEBench, and it sets not only new performance benchmarks for 1D, 2D, and 3D PDEs but also demonstrates exceptional adaptability to new physics via in-context and zero-shot learning approaches, which supports realistic engineering applications and foresight physics discovery.

The success of large-scale pre-training paradigm, exemplified by Large Language Models (LLMs), has inspired the development of Time Series Foundation Models (TSFMs). However, their application to financial candlestick (K-line) data remains limited, often underperforming non-pre-trained architectures. Moreover, existing TSFMs often overlook crucial downstream tasks such as volatility prediction and synthetic data generation. To address these limitations, we propose Kronos, a unified, scalable pre-training framework tailored to financial K-line modeling. Kronos introduces a specialized tokenizer that discretizes continuous market information into token sequences, preserving both price dynamics and trade activity patterns. We pre-train Kronos using an autoregressive objective on a massive, multi-market corpus of over 12 billion K-line records from 45 global exchanges, enabling it to learn nuanced temporal and cross-asset representations. Kronos excels in a zero-shot setting across a diverse set of financial tasks. On benchmark datasets, Kronos boosts price series forecasting RankIC by 93% over the leading TSFM and 87% over the best non-pre-trained baseline. It also achieves a 9% lower MAE in volatility forecasting and a 22% improvement in generative fidelity for synthetic K-line sequences. These results establish Kronos as a robust, versatile foundation model for end-to-end financial time series analysis. Our pre-trained model is publicly available at https://github.com/shiyu-coder/Kronos.

The development of artificial intelligence systems is transitioning from creating static, task-specific models to dynamic, agent-based systems capable of performing well in a wide range of applications. We propose an Interactive Agent Foundation Model that uses a novel multi-task agent training paradigm for training AI agents across a wide range of domains, datasets, and tasks. Our training paradigm unifies diverse pre-training strategies, including visual masked auto-encoders, language modeling, and next-action prediction, enabling a versatile and adaptable AI framework. We demonstrate the performance of our framework across three separate domains -- Robotics, Gaming AI, and Healthcare. Our model demonstrates its ability to generate meaningful and contextually relevant outputs in each area. The strength of our approach lies in its generality, leveraging a variety of data sources such as robotics sequences, gameplay data, large-scale video datasets, and textual information for effective multimodal and multi-task learning. Our approach provides a promising avenue for developing generalist, action-taking, multimodal systems.

mRNA-based vaccines have become a major focus in the pharmaceutical industry. The coding sequence as well as the Untranslated Regions (UTRs) of an mRNA can strongly influence translation efficiency, stability, degradation, and other factors that collectively determine a vaccine's effectiveness. However, optimizing mRNA sequences for those properties remains a complex challenge. Existing deep learning models often focus solely on coding region optimization, overlooking the UTRs. We present Helix-mRNA, a structured state-space-based and attention hybrid model to address these challenges. In addition to a first pre-training, a second pre-training stage allows us to specialise the model with high-quality data. We employ single nucleotide tokenization of mRNA sequences with codon separation, ensuring prior biological and structural information from the original mRNA sequence is not lost. Our model, Helix-mRNA, outperforms existing methods in analysing both UTRs and coding region properties. It can process sequences 6x longer than current approaches while using only 10% of the parameters of existing foundation models. Its predictive capabilities extend to all mRNA regions. We open-source the model (https://github.com/helicalAI/helical) and model weights (https://huggingface.co/helical-ai/helix-mRNA).

General-purpose foundation models have become increasingly important in the field of artificial intelligence. While self-supervised learning (SSL) and Masked Image Modeling (MIM) have led to promising results in building such foundation models for remote sensing, these models primarily learn low-level features, require annotated data for fine-tuning, and not applicable for retrieval and zero-shot applications due to the lack of language understanding. In response to these limitations, we propose RemoteCLIP, the first vision-language foundation model for remote sensing that aims to learn robust visual features with rich semantics, as well as aligned text embeddings for seamless downstream application. To address the scarcity of pre-training data, we leverage data scaling, converting heterogeneous annotations based on Box-to-Caption (B2C) and Mask-to-Box (M2B) conversion, and further incorporating UAV imagery, resulting a 12xlarger pretraining dataset. RemoteCLIP can be applied to a variety of downstream tasks, including zero-shot image classification, linear probing, k-NN classification, few-shot classification, image-text retrieval, and object counting. Evaluations on 16 datasets, including a newly introduced RemoteCount benchmark to test the object counting ability, show that RemoteCLIP consistently outperforms baseline foundation models across different model scales. Impressively, RemoteCLIP outperform previous SoTA by 9.14% mean recall on RSICD dataset and by 8.92% on RSICD dataset. For zero-shot classification, our RemoteCLIP outperform CLIP baseline by up to 6.39% average accuracy on 12 downstream datasets.

Foundation models have demonstrated remarkable capabilities across various domains, but developing analogous models for knowledge graphs presents unique challenges due to their dynamic nature and the need for cross-domain reasoning. To address these issues, we introduce \textsc{GraphOracle}, a relation-centric foundation model that unifies reasoning across knowledge graphs by converting them into Relation-Dependency Graphs (RDG), explicitly encoding compositional patterns with fewer edges than prior methods. A query-dependent attention mechanism is further developed to learn inductive representations for both relations and entities. Pre-training on diverse knowledge graphs, followed by minutes-level fine-tuning, enables effective generalization to unseen entities, relations, and entire graphs. Through comprehensive experiments on 31 diverse benchmarks spanning transductive, inductive, and cross-domain settings, we demonstrate consistent state-of-the-art performance with minimal adaptation, improving the prediction performance by up to 35\% compared to the strongest baselines.

Advanced interpretation of hyperspectral remote sensing images benefits many precise Earth observation tasks. Recently, visual foundation models have promoted the remote sensing interpretation but concentrating on RGB and multispectral images. Due to the varied hyperspectral channels,existing foundation models would face image-by-image tuning situation, imposing great pressure on hardware and time resources. In this paper, we propose a tuning-free hyperspectral foundation model called HyperFree, by adapting the existing visual prompt engineering. To process varied channel numbers, we design a learned weight dictionary covering full-spectrum from 0.4 sim 2.5 , mum, supporting to build the embedding layer dynamically. To make the prompt design more tractable, HyperFree can generate multiple semantic-aware masks for one prompt by treating feature distance as semantic-similarity. After pre-training HyperFree on constructed large-scale high-resolution hyperspectral images, HyperFree (1 prompt) has shown comparable results with specialized models (5 shots) on 5 tasks and 11 datasets.Code and dataset are accessible at https://rsidea.whu.edu.cn/hyperfree.htm.

Multiple instance learning (MIL) is the most widely used framework in computational pathology, encompassing sub-typing, diagnosis, prognosis, and more. However, the existing MIL paradigm typically requires an offline instance feature extractor, such as a pre-trained ResNet or a foundation model. This approach lacks the capability for feature fine-tuning within the specific downstream tasks, limiting its adaptability and performance. To address this issue, we propose a Re-embedded Regional Transformer (R^2T) for re-embedding the instance features online, which captures fine-grained local features and establishes connections across different regions. Unlike existing works that focus on pre-training powerful feature extractor or designing sophisticated instance aggregator, R^2T is tailored to re-embed instance features online. It serves as a portable module that can seamlessly integrate into mainstream MIL models. Extensive experimental results on common computational pathology tasks validate that: 1) feature re-embedding improves the performance of MIL models based on ResNet-50 features to the level of foundation model features, and further enhances the performance of foundation model features; 2) the R^2T can introduce more significant performance improvements to various MIL models; 3) R^2T-MIL, as an R^2T-enhanced AB-MIL, outperforms other latest methods by a large margin.The code is available at: https://github.com/DearCaat/RRT-MIL.

Foundation models have demonstrated remarkable potential in medical domain. However, their application to complex cardiovascular diagnostics remains underexplored. In this paper, we present Cardiac-CLIP, a multi-modal foundation model designed for 3D cardiac CT images. Cardiac-CLIP is developed through a two-stage pre-training strategy. The first stage employs a 3D masked autoencoder (MAE) to perform self-supervised representation learning from large-scale unlabeled volumetric data, enabling the visual encoder to capture rich anatomical and contextual features. In the second stage, contrastive learning is introduced to align visual and textual representations, facilitating cross-modal understanding. To support the pre-training, we collect 16641 real clinical CT scans, supplemented by 114k publicly available data. Meanwhile, we standardize free-text radiology reports into unified templates and construct the pathology vectors according to diagnostic attributes, based on which the soft-label matrix is generated to supervise the contrastive learning process. On the other hand, to comprehensively evaluate the effectiveness of Cardiac-CLIP, we collect 6,722 real-clinical data from 12 independent institutions, along with the open-source data to construct the evaluation dataset. Specifically, Cardiac-CLIP is comprehensively evaluated across multiple tasks, including cardiovascular abnormality classification, information retrieval and clinical analysis. Experimental results demonstrate that Cardiac-CLIP achieves state-of-the-art performance across various downstream tasks in both internal and external data. Particularly, Cardiac-CLIP exhibits great effectiveness in supporting complex clinical tasks such as the prospective prediction of acute coronary syndrome, which is notoriously difficult in real-world scenarios.

Cardiac magnetic resonance (CMR) is a key investigation in clinical cardiovascular medicine and has been used extensively in population research. However, extracting clinically important measurements such as ejection fraction for diagnosing cardiovascular diseases remains time-consuming and subjective. We developed CineMA, a foundation AI model automating these tasks with limited labels. CineMA is a self-supervised autoencoder model trained on 74,916 cine CMR studies to reconstruct images from masked inputs. After fine-tuning, it was evaluated across eight datasets on 23 tasks from four categories: ventricle and myocardium segmentation, left and right ventricle ejection fraction calculation, disease detection and classification, and landmark localisation. CineMA is the first foundation model for cine CMR to match or outperform convolutional neural networks (CNNs). CineMA demonstrated greater label efficiency than CNNs, achieving comparable or better performance with fewer annotations. This reduces the burden of clinician labelling and supports replacing task-specific training with fine-tuning foundation models in future cardiac imaging applications. Models and code for pre-training and fine-tuning are available at https://github.com/mathpluscode/CineMA, democratising access to high-performance models that otherwise require substantial computational resources, promoting reproducibility and accelerating clinical translation.

To mimic human vision with the way of recognizing the diverse and open world, foundation vision models are much critical. While recent techniques of self-supervised learning show the promising potentiality of this mission, we argue that signals from labelled data are also important for common-sense recognition, and properly chosen pre-text tasks can facilitate the efficiency of vision representation learning. To this end, we propose a novel pre-training framework by adopting both self-supervised and supervised visual pre-text tasks in a multi-task manner. Specifically, given an image, we take a heuristic way by considering its intrinsic style properties, inside objects with their locations and correlations, and how it looks like in 3D space for basic visual understanding. However, large-scale object bounding boxes and correlations are usually hard to achieve. Alternatively, we develop a hybrid method by leveraging both multi-label classification and self-supervised learning. On the one hand, under the multi-label supervision, the pre-trained model can explore the detailed information of an image, e.g., image types, objects, and part of semantic relations. On the other hand, self-supervised learning tasks, with respect to Masked Image Modeling (MIM) and contrastive learning, can help the model learn pixel details and patch correlations. Results show that our pre-trained models can deliver results on par with or better than state-of-the-art (SOTA) results on multiple visual tasks. For example, with a vanilla Swin-B backbone, we achieve 85.3\% top-1 accuracy on ImageNet-1K classification, 47.9 box AP on COCO object detection for Mask R-CNN, and 50.6 mIoU on ADE-20K semantic segmentation when using Upernet. The performance shows the ability of our vision foundation model to serve general purpose vision tasks.

In this paper, we introduce MIO, a novel foundation model built on multimodal tokens, capable of understanding and generating speech, text, images, and videos in an end-to-end, autoregressive manner. While the emergence of large language models (LLMs) and multimodal large language models (MM-LLMs) propels advancements in artificial general intelligence through their versatile capabilities, they still lack true any-to-any understanding and generation. Recently, the release of GPT-4o has showcased the remarkable potential of any-to-any LLMs for complex real-world tasks, enabling omnidirectional input and output across images, speech, and text. However, it is closed-source and does not support the generation of multimodal interleaved sequences. To address this gap, we present MIO, which is trained on a mixture of discrete tokens across four modalities using causal multimodal modeling. MIO undergoes a four-stage training process: (1) alignment pre-training, (2) interleaved pre-training, (3) speech-enhanced pre-training, and (4) comprehensive supervised fine-tuning on diverse textual, visual, and speech tasks. Our experimental results indicate that MIO exhibits competitive, and in some cases superior, performance compared to previous dual-modal baselines, any-to-any model baselines, and even modality-specific baselines. Moreover, MIO demonstrates advanced capabilities inherent to its any-to-any feature, such as interleaved video-text generation, chain-of-visual-thought reasoning, visual guideline generation, instructional image editing, etc.

The non-invasive assessment of increasingly incidentally discovered renal masses is a critical challenge in urologic oncology, where diagnostic uncertainty frequently leads to the overtreatment of benign or indolent tumors. In this study, we developed and validated RenalCLIP using a dataset of 27,866 CT scans from 8,809 patients across nine Chinese medical centers and the public TCIA cohort, a visual-language foundation model for characterization, diagnosis and prognosis of renal mass. The model was developed via a two-stage pre-training strategy that first enhances the image and text encoders with domain-specific knowledge before aligning them through a contrastive learning objective, to create robust representations for superior generalization and diagnostic precision. RenalCLIP achieved better performance and superior generalizability across 10 core tasks spanning the full clinical workflow of kidney cancer, including anatomical assessment, diagnostic classification, and survival prediction, compared with other state-of-the-art general-purpose CT foundation models. Especially, for complicated task like recurrence-free survival prediction in the TCIA cohort, RenalCLIP achieved a C-index of 0.726, representing a substantial improvement of approximately 20% over the leading baselines. Furthermore, RenalCLIP's pre-training imparted remarkable data efficiency; in the diagnostic classification task, it only needs 20% training data to achieve the peak performance of all baseline models even after they were fully fine-tuned on 100% of the data. Additionally, it achieved superior performance in report generation, image-text retrieval and zero-shot diagnosis tasks. Our findings establish that RenalCLIP provides a robust tool with the potential to enhance diagnostic accuracy, refine prognostic stratification, and personalize the management of patients with kidney cancer.

We introduce Ψ_0 (Psi-Zero), an open foundation model to address challenging humanoid loco-manipulation tasks. While existing approaches often attempt to address this fundamental problem by co-training on large and diverse human and humanoid data, we argue that this strategy is suboptimal due to the fundamental kinematic and motion disparities between humans and humanoid robots. Therefore, data efficiency and model performance remain unsatisfactory despite the considerable data volume. To address this challenge, \ours\;decouples the learning process to maximize the utility of heterogeneous data sources. Specifically, we propose a staged training paradigm with different learning objectives: First, we autoregressively pre-train a VLM backbone on large-scale egocentric human videos to acquire generalizable visual-action representations. Then, we post-train a flow-based action expert on high-quality humanoid robot data to learn precise robot joint control. Our research further identifies a critical yet often overlooked data recipe: in contrast to approaches that scale with noisy Internet clips or heterogeneous cross-embodiment robot datasets, we demonstrate that pre-training on high-quality egocentric human manipulation data followed by post-training on domain-specific real-world humanoid trajectories yields superior performance. Extensive real-world experiments demonstrate that \ours\ achieves the best performance using only about 800 hours of human video data and 30 hours of real-world robot data, outperforming baselines pre-trained on more than 10times as much data by over 40\% in overall success rate across multiple tasks. We will open-source the entire ecosystem to the community, including a data processing and training pipeline, a humanoid foundation model, and a real-time action inference engine.

Large language models (LLMs) trained on text demonstrated remarkable results on natural language processing (NLP) tasks. These models have been adapted to decipher the language of DNA, where sequences of nucleotides act as "words" that encode genomic functions. However, the genome differs fundamentally from natural language, as it lacks clearly defined words or a consistent grammar. Although DNA language models (DNALMs) such as DNABERT, GENA-LM have achieved high level of performance on genome-related biological tasks, these models do not encode biological functions in the presence of sequence variations. To address this problem, we pre-train foundation models that effectively integrate sequence variations, in particular Single Nucleotide Polymorphisms (SNPs), as they underlie important biological functions. Specifically, we use ModernBERT to pre-train two different Biomedical Foundation Models (BMFM), namely, BMFM-DNA-REF in which the model is trained with sequences of varying lengths along with their reverse complements derived from the reference genome and BMFM-DNA-SNP in which the model is trained with sequences created using a novel representation scheme that encodes sequence variations. Our findings indicate that integrating sequence variations into DNALMs helps capture the biological functions as seen in improvements on all fine-tuning tasks. To explore the model's practical utility, we experimented with various strategies for SNP imputation on promoter detection task introduced in DNABERT-2. However, we acknowledge that the current benchmarks are limited in their ability to fully evaluate these models. To enable more comprehensive assessment in the future and encourage community contributions, we release our models through HuggingFace and the code to reproduce the results at https://github.com/BiomedSciAI/biomed-multi-omic

Recent advances in music foundation models have improved audio representation learning, yet their effectiveness across diverse musical traditions remains limited. We introduce CultureMERT-95M, a multi-culturally adapted foundation model developed to enhance cross-cultural music representation learning and understanding. To achieve this, we propose a two-stage continual pre-training strategy that integrates learning rate re-warming and re-decaying, enabling stable adaptation even with limited computational resources. Training on a 650-hour multi-cultural data mix, comprising Greek, Turkish, and Indian music traditions, results in an average improvement of 4.9% in ROC-AUC and AP across diverse non-Western music auto-tagging tasks, surpassing prior state-of-the-art, with minimal forgetting on Western-centric benchmarks. We further investigate task arithmetic, an alternative approach to multi-cultural adaptation that merges single-culture adapted models in the weight space. Task arithmetic performs on par with our multi-culturally trained model on non-Western auto-tagging tasks and shows no regression on Western datasets. Cross-cultural evaluation reveals that single-culture models transfer with varying effectiveness across musical traditions, whereas the multi-culturally adapted model achieves the best overall performance. To support research on world music representation learning, we publicly release CultureMERT-95M and CultureMERT-TA-95M, fostering the development of more culturally aware music foundation models.

Generic time-series foundation models transfer poorly to wireless network telemetry whose signals are bursty, zero-inflated, and coupled across protocol layers. We present APEX, a network-native, decoder-only transformer for forecasting enterprise AP telemetry, and evaluate it on DHCP degradation as a representative network task. APEX is pre-trained on 10-channel multivariate telemetry from ~4,500 production wireless networks (~100K AP time series, 34 metrics per AP), and is available as APEX-Large (269M, cloud) and APEX-Edge (10.5M, edge). On a 192-step (4-day) DHCP degradation benchmark, APEX-Large reduces MAE by 18% over the strongest foundation-model baseline (Toto) and 38% over SARIMA, with anomaly-detection F1 = 0.93, while APEX-Edge enables sub-second, privacy-preserving inference on AP-class edge hardware. These results suggest network-native pre-training is a practical foundation for proactive wireless operations.

Ultrasound (US) is one of the most widely used medical imaging modalities, thanks to its low cost, portability, real-time feedback, and absence of ionizing radiation. However, US image interpretation remains highly operator-dependent and varies significantly across anatomical regions, acquisition protocols, and device types. These variations, along with unique challenges such as speckle, low contrast, and limited standardized annotations, hinder the development of generalizable, label-efficient ultrasound AI models. In this paper, we propose OpenUS, the first reproducible, open-source ultrasound foundation model built on a large collection of public data. OpenUS employs a vision Mamba backbone, capturing both local and global long-range dependencies across the image. To extract rich features during pre-training, we introduce a novel self-adaptive masking framework that combines contrastive learning with masked image modeling. This strategy integrates the teacher's attention map with student reconstruction loss, adaptively refining clinically-relevant masking to enhance pre-training effectiveness. OpenUS also applies a dynamic learning schedule to progressively adjust the difficulty of the pre-training process. To develop the foundation model, we compile the largest to-date public ultrasound dataset comprising over 308K images from 42 publicly available datasets, covering diverse anatomical regions, institutions, imaging devices, and disease types. Our pre-trained OpenUS model can be easily adapted to specific downstream tasks by serving as a backbone for label-efficient fine-tuning. Code is available at https://github.com/XZheng0427/OpenUS.

Relational Databases (RDBs) are the backbone of modern business, yet they lack foundation models comparable to those in text or vision. A key obstacle is that high-quality RDBs are private, scarce and structurally heterogeneous, making internet-scale pre-training infeasible. To overcome this data scarcity, We introduce RDB-PFN, the first relational foundation model trained purely via synthetic data. Inspired by Prior-Data Fitted Networks (PFNs) where synthetic data generated from Structural Causal Models (SCMs) enables reasoning on single tables, we design a Relational Prior Generator to create an infinite stream of diverse RDBs from scratch. Pre-training on over 2 million synthetic single-table and relational tasks, RDB-PFN learns to adapt to any new database instantly via genuine in-context learning. Experiments verify RDB-PFN achieves strong few-shot performance on 19 real-world relational prediction tasks, outperforming graph-based and single-table foundation-model baselines (given the same DFS-linearized inputs), while using a lightweight architecture and fast inference. The code is available at https://github.com/MuLabPKU/RDBPFN

Foundation models for zero-shot time series forecasting face challenges in efficient long-horizon prediction and reproducibility, with existing synthetic-only approaches underperforming on challenging benchmarks. This paper presents TempoPFN, a univariate time series foundation model based on linear Recurrent Neural Networks (RNNs) pre-trained exclusively on synthetic data. The model uses a GatedDeltaProduct architecture with state-weaving for fully parallelizable training across sequence lengths, eliminating the need for windowing or summarization techniques while maintaining robust temporal state-tracking. Our comprehensive synthetic data pipeline unifies diverse generators, including stochastic differential equations, Gaussian processes, and audio synthesis, with novel augmentations. In zero-shot evaluations on the Gift-Eval benchmark, TempoPFN achieves top-tier competitive performance, outperforming all existing synthetic-only approaches and surpassing the vast majority of models trained on real-world data, while being more efficient than existing baselines by leveraging fully parallelizable training and inference. We open-source our complete data generation pipeline and training code, providing a reproducible foundation for future research.

Electroencephalography (EEG) signals provide critical insights for applications in disease diagnosis and healthcare. However, the scarcity of labeled EEG data poses a significant challenge. Foundation models offer a promising solution by leveraging large-scale unlabeled data through pre-training, enabling strong performance across diverse tasks. While both temporal dynamics and inter-channel relationships are vital for understanding EEG signals, existing EEG foundation models primarily focus on the former, overlooking the latter. To address this limitation, we propose Graph-Enhanced EEG Foundation Model (GEFM), a novel foundation model for EEG that integrates both temporal and inter-channel information. Our architecture combines Graph Neural Networks (GNNs), which effectively capture relational structures, with a masked autoencoder to enable efficient pre-training. We evaluated our approach using three downstream tasks and experimented with various GNN architectures. The results demonstrate that our proposed model, particularly when employing the GCN architecture with optimized configurations, consistently outperformed baseline methods across all tasks. These findings suggest that our model serves as a robust foundation model for EEG analysis.

Foundation Models (FMs) serve as a general class for the development of artificial intelligence systems, offering broad potential for generalization across a spectrum of downstream tasks. Despite extensive research into self-supervised learning as the cornerstone of FMs, several outstanding issues persist in Graph Foundation Models that rely on graph self-supervised learning, namely: 1) Homogenization. The extent of generalization capability on downstream tasks remains unclear. 2) Scalability. It is unknown how effectively these models can scale to large datasets. 3) Efficiency. The training time and memory usage of these models require evaluation. 4) Training Stop Criteria. Determining the optimal stopping strategy for pre-training across multiple tasks to maximize performance on downstream tasks. To address these questions, we have constructed a rigorous benchmark that thoroughly analyzes and studies the generalization and scalability of self-supervised Graph Neural Network (GNN) models. Regarding generalization, we have implemented and compared the performance of various self-supervised GNN models, trained to generate node representations, across tasks such as node classification, link prediction, and node clustering. For scalability, we have compared the performance of various models after training using full-batch and mini-batch strategies. Additionally, we have assessed the training efficiency of these models by conducting experiments to test their GPU memory usage and throughput. Through these experiments, we aim to provide insights to motivate future research. The code for this benchmark is publicly available at https://github.com/NYUSHCS/GraphFM.

Molecular knowledge resides within three different modalities of information sources: molecular structures, biomedical documents, and knowledge bases. Effective incorporation of molecular knowledge from these modalities holds paramount significance in facilitating biomedical research. However, existing multimodal molecular foundation models exhibit limitations in capturing intricate connections between molecular structures and texts, and more importantly, none of them attempt to leverage a wealth of molecular expertise derived from knowledge graphs. In this study, we introduce MolFM, a multimodal molecular foundation model designed to facilitate joint representation learning from molecular structures, biomedical texts, and knowledge graphs. We propose cross-modal attention between atoms of molecular structures, neighbors of molecule entities and semantically related texts to facilitate cross-modal comprehension. We provide theoretical analysis that our cross-modal pre-training captures local and global molecular knowledge by minimizing the distance in the feature space between different modalities of the same molecule, as well as molecules sharing similar structures or functions. MolFM achieves state-of-the-art performance on various downstream tasks. On cross-modal retrieval, MolFM outperforms existing models with 12.13% and 5.04% absolute gains under the zero-shot and fine-tuning settings, respectively. Furthermore, qualitative analysis showcases MolFM's implicit ability to provide grounding from molecular substructures and knowledge graphs. Code and models are available on https://github.com/BioFM/OpenBioMed.

In this work, we introduce Reinforcement Pre-Training (RPT) as a new scaling paradigm for large language models and reinforcement learning (RL). Specifically, we reframe next-token prediction as a reasoning task trained using RL, where it receives verifiable rewards for correctly predicting the next token for a given context. RPT offers a scalable method to leverage vast amounts of text data for general-purpose RL, rather than relying on domain-specific annotated answers. By incentivizing the capability of next-token reasoning, RPT significantly improves the language modeling accuracy of predicting the next tokens. Moreover, RPT provides a strong pre-trained foundation for further reinforcement fine-tuning. The scaling curves show that increased training compute consistently improves the next-token prediction accuracy. The results position RPT as an effective and promising scaling paradigm to advance language model pre-training.

Contrastive Language-Image Pre-training (CLIP) has been a celebrated method for training vision encoders to generate image/text representations facilitating various applications. Recently, CLIP has been widely adopted as the vision backbone of multimodal large language models (MLLMs) to connect image inputs for language interactions. The success of CLIP as a vision-language foundation model relies on aligning web-crawled noisy text annotations at image levels. Nevertheless, such criteria may become insufficient for downstream tasks in need of fine-grained vision representations, especially when region-level understanding is demanding for MLLMs. In this paper, we improve the localization capability of CLIP with several advances. We propose a pre-training method called Contrastive Localized Language-Image Pre-training (CLOC) by complementing CLIP with region-text contrastive loss and modules. We formulate a new concept, promptable embeddings, of which the encoder produces image embeddings easy to transform into region representations given spatial hints. To support large-scale pre-training, we design a visually-enriched and spatially-localized captioning framework to effectively generate region-text pseudo-labels at scale. By scaling up to billions of annotated images, CLOC enables high-quality regional embeddings for image region recognition and retrieval tasks, and can be a drop-in replacement of CLIP to enhance MLLMs, especially on referring and grounding tasks.

Large-scale self-supervised pre-training has paved the way for one foundation model to handle many different vision tasks. Most pre-training methodologies train a single model of a certain size at one time. Nevertheless, various computation or storage constraints in real-world scenarios require substantial efforts to develop a series of models with different sizes to deploy. Thus, in this study, we propose a novel tri-branch self-supervised training framework, termed as POA (Pre-training Once for All), to tackle this aforementioned issue. Our approach introduces an innovative elastic student branch into a modern self-distillation paradigm. At each pre-training step, we randomly sample a sub-network from the original student to form the elastic student and train all branches in a self-distilling fashion. Once pre-trained, POA allows the extraction of pre-trained models of diverse sizes for downstream tasks. Remarkably, the elastic student facilitates the simultaneous pre-training of multiple models with different sizes, which also acts as an additional ensemble of models of various sizes to enhance representation learning. Extensive experiments, including k-nearest neighbors, linear probing evaluation and assessments on multiple downstream tasks demonstrate the effectiveness and advantages of our POA. It achieves state-of-the-art performance using ViT, Swin Transformer and ResNet backbones, producing around a hundred models with different sizes through a single pre-training session. The code is available at: https://github.com/Qichuzyy/POA.

Data quality determines foundation model performance, yet systematic processing frameworks are lacking. We introduce Data Darwinism, a ten-level taxonomy (L0-L9) that conceptualizes data-model co-evolution: advanced models produce superior data for next-generation systems. We validate this on scientific literature by constructing Darwin-Science, a 900B-token corpus (L0-L5). We identify a learnability gap in raw scientific text, which we bridge via L4 (Generative Refinement) and L5 (Cognitive Completion) using frontier LLMs to explicate reasoning and terminology. To ensure rigorous attribution, we pre-trained daVinci-origin-3B/7B models from scratch, excluding scientific content to create contamination-free baselines. After 600B tokens of continued pre-training, Darwin-Science outperforms baselines by +2.12 (3B) and +2.95 (7B) points across 20+ benchmarks, rising to +5.60 and +8.40 points on domain-aligned tasks. Systematic progression to L5 yields a +1.36 total gain, confirming that higher-level processing unlocks latent data value. We release the Darwin-Science corpus and daVinci-origin models to enable principled, co-evolutionary development.

Time series foundation models (TSFMs) offer strong zero-shot forecasting via large-scale pre-training, yet fine-tuning remains critical for boosting performance in domains with limited public data. With the growing number of TSFMs, efficiently identifying the best model for downstream fine-tuning becomes increasingly challenging. In this work, we introduce TimeTic, a transferability estimation framework that recasts model selection as an in-context-learning problem: given observations on known (source) datasets, it predicts how a TSFM will perform after fine-tuning on a downstream (target) dataset. TimeTic flexibly organizes the observed model-data relationships as contextual information, allowing it to adapt seamlessly to various test-time scenarios. Leveraging the natural tabular structure formed by dataset meta-features, model characteristics, and fine-tuned performance, we employ tabular foundation models to serve as in-context learners. We further introduce a novel model characterization based on entropy evolution across model layers, capturing embedding-space distinctions and enabling TimeTic to generalize across arbitrary model sets. We establish a comprehensive benchmark for transferability estimation including 10 datasets, 10 foundation models, and 3 forecasting tasks. On this benchmark, TimeTic's estimation demonstrates strong alignment with actual fine-tuned performance for previously unseen datasets, achieving a mean rank correlation of approximately 0.6 and a 30% improvement compared to using zero-shot performance as the transferability score.

Deep learning has enabled the development of highly robust foundation models for various pathological tasks across diverse diseases and patient cohorts. Among these models, vision-language pre-training, which leverages large-scale paired data to align pathology image and text embedding spaces, and provides a novel zero-shot paradigm for downstream tasks. However, existing models have been primarily data-driven and lack the incorporation of domain-specific knowledge, which limits their performance in cancer diagnosis, especially for rare tumor subtypes. To address this limitation, we establish a Knowledge-enhanced Pathology (KEEP) foundation model that harnesses disease knowledge to facilitate vision-language pre-training. Specifically, we first construct a disease knowledge graph (KG) that covers 11,454 human diseases with 139,143 disease attributes, including synonyms, definitions, and hypernym relations. We then systematically reorganize the millions of publicly available noisy pathology image-text pairs, into 143K well-structured semantic groups linked through the hierarchical relations of the disease KG. To derive more nuanced image and text representations, we propose a novel knowledge-enhanced vision-language pre-training approach that integrates disease knowledge into the alignment within hierarchical semantic groups instead of unstructured image-text pairs. Validated on 18 diverse benchmarks with more than 14,000 whole slide images (WSIs), KEEP achieves state-of-the-art performance in zero-shot cancer diagnostic tasks. Notably, for cancer detection, KEEP demonstrates an average sensitivity of 89.8% at a specificity of 95.0% across 7 cancer types. For cancer subtyping, KEEP achieves a median balanced accuracy of 0.456 in subtyping 30 rare brain cancers, indicating strong generalizability for diagnosing rare tumors.

The lack of large and diverse training data on Computer-Aided Diagnosis (CAD) in breast cancer detection has been one of the concerns that impedes the adoption of the system. Recently, pre-training with large-scale image text datasets via Vision-Language models (VLM) (\eg CLIP) partially addresses the issue of robustness and data efficiency in computer vision (CV). This paper proposes Mammo-CLIP, the first VLM pre-trained on a substantial amount of screening mammogram-report pairs, addressing the challenges of dataset diversity and size. Our experiments on two public datasets demonstrate strong performance in classifying and localizing various mammographic attributes crucial for breast cancer detection, showcasing data efficiency and robustness similar to CLIP in CV. We also propose Mammo-FActOR, a novel feature attribution method, to provide spatial interpretation of representation with sentence-level granularity within mammography reports. Code is available publicly: https://github.com/batmanlab/Mammo-CLIP.

Self-supervised learning has enabled large-scale pre-training on 2D natural images, producing general-purpose visual representations that transfer effectively across tasks. However, many medical imaging modalities, such as CT scans, are inherently three-dimensional and differ fundamentally from natural images in both structure and semantics. Volumetric modalities capture spatial continuity, organ anatomy, and intensity-based tissue properties (e.g., Hounsfield Units), which are not adequately modeled by 2D pre-training. To bridge this gap, we introduce CoralBay, a self-distillation framework that extends DINO by using a hierarchical 3D Swin backbone and applying self-distillation to concatenated multi-scale features, enabling data-efficient self-supervised learning of rich spatial representations that encode both global semantics and fine-grained local structure. As a result, CoralBay transfers effectively to a wide range of downstream radiological tasks, demonstrating strong and consistent performance across diverse anatomical targets. In addition, we contribute to the open-source \eva framework by introducing a public, reproducible 3D radiology leaderboard that unifies multiple datasets and establishes a standardized benchmark for evaluating volumetric representation learning methods.

X-ray angiography is the gold standard imaging modality for cardiovascular diseases. However, current deep learning approaches for X-ray angiogram analysis are severely constrained by the scarcity of annotated data. While large-scale self-supervised learning (SSL) has emerged as a promising solution, its potential in this domain remains largely unexplored, primarily due to the lack of effective SSL frameworks and large-scale datasets. To bridge this gap, we introduce a vascular anatomy-aware masked image modeling (VasoMIM) framework that explicitly integrates domain-specific anatomical knowledge. Specifically, VasoMIM comprises two key designs: an anatomy-guided masking strategy and an anatomical consistency loss. The former strategically masks vessel-containing patches to compel the model to learn robust vascular semantics, while the latter preserves structural consistency of vessels between original and reconstructed images, enhancing the discriminability of the learned representations. In conjunction with VasoMIM, we curate XA-170K, the largest X-ray angiogram pre-training dataset to date. We validate VasoMIM on four downstream tasks across six datasets, where it demonstrates superior transferability and achieves state-of-the-art performance compared to existing methods. These findings highlight the significant potential of VasoMIM as a foundation model for advancing a wide range of X-ray angiogram analysis tasks. VasoMIM and XA-170K will be available at https://github.com/Dxhuang-CASIA/XA-SSL.

Inspired by the success of unsupervised pre-training paradigms, researchers have applied these approaches to DNA pre-training. However, we argue that these approaches alone yield suboptimal results because pure DNA sequences lack sufficient information, since their functions are regulated by genomic profiles like chromatin accessibility. Here, we demonstrate that supervised training for genomic profile prediction serves as a more effective alternative to pure sequence pre-training. Furthermore, considering the multi-species and multi-profile nature of genomic profile prediction, we introduce our Species-Profile Adaptive Collaborative Experts (SPACE) that leverages Mixture of Experts (MoE) to better capture the relationships between DNA sequences across different species and genomic profiles, thereby learning more effective DNA representations. Through extensive experiments across various tasks, our model achieves state-of-the-art performance, establishing that DNA models trained with supervised genomic profiles serve as powerful DNA representation learners. The code is available at https://github.com/ZhuJiwei111/SPACE.

Pre-training has been investigated to improve the efficiency and performance of training neural operators in data-scarce settings. However, it is largely in its infancy due to the inherent complexity and diversity, such as long trajectories, multiple scales and varying dimensions of partial differential equations (PDEs) data. In this paper, we present a new auto-regressive denoising pre-training strategy, which allows for more stable and efficient pre-training on PDE data and generalizes to various downstream tasks. Moreover, by designing a flexible and scalable model architecture based on Fourier attention, we can easily scale up the model for large-scale pre-training. We train our PDE foundation model with up to 0.5B parameters on 10+ PDE datasets with more than 100k trajectories. Extensive experiments show that we achieve SOTA on these benchmarks and validate the strong generalizability of our model to significantly enhance performance on diverse downstream PDE tasks like 3D data. Code is available at https://github.com/thu-ml/DPOT.

A major challenge in computational research in 3D medical imaging is the lack of comprehensive datasets. Addressing this issue, our study introduces CT-RATE, the first 3D medical imaging dataset that pairs images with textual reports. CT-RATE consists of 25,692 non-contrast chest CT volumes, expanded to 50,188 through various reconstructions, from 21,304 unique patients, along with corresponding radiology text reports. Leveraging CT-RATE, we developed CT-CLIP, a CT-focused contrastive language-image pre-training framework. As a versatile, self-supervised model, CT-CLIP is designed for broad application and does not require task-specific training. Remarkably, CT-CLIP outperforms state-of-the-art, fully supervised methods in multi-abnormality detection across all key metrics, thus eliminating the need for manual annotation. We also demonstrate its utility in case retrieval, whether using imagery or textual queries, thereby advancing knowledge dissemination. The open-source release of CT-RATE and CT-CLIP marks a significant advancement in medical AI, enhancing 3D imaging analysis and fostering innovation in healthcare.

The landscape of high-performance image generation models is currently dominated by proprietary systems, such as Nano Banana Pro and Seedream 4.0. Leading open-source alternatives, including Qwen-Image, Hunyuan-Image-3.0 and FLUX.2, are characterized by massive parameter counts (20B to 80B), making them impractical for inference, and fine-tuning on consumer-grade hardware. To address this gap, we propose Z-Image, an efficient 6B-parameter foundation generative model built upon a Scalable Single-Stream Diffusion Transformer (S3-DiT) architecture that challenges the "scale-at-all-costs" paradigm. By systematically optimizing the entire model lifecycle -- from a curated data infrastructure to a streamlined training curriculum -- we complete the full training workflow in just 314K H800 GPU hours (approx. $630K). Our few-step distillation scheme with reward post-training further yields Z-Image-Turbo, offering both sub-second inference latency on an enterprise-grade H800 GPU and compatibility with consumer-grade hardware (<16GB VRAM). Additionally, our omni-pre-training paradigm also enables efficient training of Z-Image-Edit, an editing model with impressive instruction-following capabilities. Both qualitative and quantitative experiments demonstrate that our model achieves performance comparable to or surpassing that of leading competitors across various dimensions. Most notably, Z-Image exhibits exceptional capabilities in photorealistic image generation and bilingual text rendering, delivering results that rival top-tier commercial models, thereby demonstrating that state-of-the-art results are achievable with significantly reduced computational overhead. We publicly release our code, weights, and online demo to foster the development of accessible, budget-friendly, yet state-of-the-art generative models.

We introduce Timer-S1, a strong Mixture-of-Experts (MoE) time series foundation model with 8.3B total parameters, 0.75B activated parameters for each token, and a context length of 11.5K. To overcome the scalability bottleneck in existing pre-trained time series foundation models, we perform Serial Scaling in three dimensions: model architecture, dataset, and training pipeline. Timer-S1 integrates sparse TimeMoE blocks and generic TimeSTP blocks for Serial-Token Prediction (STP), a generic training objective that adheres to the serial nature of forecasting. The proposed paradigm introduces serial computations to improve long-term predictions while avoiding costly rolling-style inference and pronounced error accumulation in the standard next-token prediction. Pursuing a high-quality and unbiased training dataset, we curate TimeBench, a corpus with one trillion time points, and apply meticulous data augmentation to mitigate predictive bias. We further pioneer a post-training stage, including continued pre-training and long-context extension, to enhance short-term and long-context performance. Evaluated on the large-scale GIFT-Eval leaderboard, Timer-S1 achieves state-of-the-art forecasting performance, attaining the best MASE and CRPS scores as a pre-trained model. Timer-S1 will be released to facilitate further research.

Multi-turn long-horizon planning is critical for foundation model agents, yet how to fundamentally improve it remains unclear. Existing models are trained on uncontrollable and opaque Internet data, making it difficult to identify how planning ability is acquired, shaped, and integrated. To address this challenge, we introduce a unified and controlled multi-turn environment that enables precise control. It allows systematically study long-horizon planning across three stages. (1) Planning ability acquisition during pre-training. We study data format, distribution, and quality. Explicit world model construction through CoT state transition modeling yields stronger long-horizon generalization. Atomic skills alone are insufficient for compositional generalization, whereas a litte long-horizon data works. Moreover, suboptimal trajectories severely impair performance because errors amplify over long horizons. (2) Planning ability shaping via GRPO and OPD post-training. Through mutual information, we distinguish general planning patterns from task-specific planning knowledge. For planning patterns, we identify three application regions of post-training: unnecessary, effective, and unsupported. OPD has a broader effective region than GRPO under low-quality and long-horizon settings, as it provides more consistent update directions. For planning knowledge, distilling unseen procedures from a teacher with different knowledge may impair student's prior world modeling without fully establishing new knowledge. (3) Planning ability integration through MOPD post-training. We show that multi-teacher on-policy distillation (MOPD) integrates capabilities by converging to shared planning-pattern across environments. Compatible patterns enable cross-environment generalization, partially shared patterns support continual learning, while completely conflicting patterns cause severe interference.

Modern astronomical surveys, such as the Euclid mission, produce high-dimensional, multi-modal data sets that include imaging and spectroscopic information for millions of galaxies. These data serve as an ideal benchmark for large, pre-trained multi-modal models, which can leverage vast amounts of unlabelled data. In this work, we present the first exploration of Euclid data with AstroPT, an autoregressive multi-modal foundation model trained on approximately 300 000 optical and infrared Euclid images and spectral energy distributions (SEDs) from the first Euclid Quick Data Release. We compare self-supervised pre-training with baseline fully supervised training across several tasks: galaxy morphology classification; redshift estimation; similarity searches; and outlier detection. Our results show that: (a) AstroPT embeddings are highly informative, correlating with morphology and effectively isolating outliers; (b) including infrared data helps to isolate stars, but degrades the identification of edge-on galaxies, which are better captured by optical images; (c) simple fine-tuning of these embeddings for photometric redshift and stellar mass estimation outperforms a fully supervised approach, even when using only 1% of the training labels; and (d) incorporating SED data into AstroPT via a straightforward multi-modal token-chaining method improves photo-z predictions, and allow us to identify potentially more interesting anomalies (such as ringed or interacting galaxies) compared to a model pre-trained solely on imaging data.

Non-ideal measurement computed tomography (NICT), which sacrifices optimal imaging standards for new advantages in CT imaging, is expanding the clinical application scope of CT images. However, with the reduction of imaging standards, the image quality has also been reduced, extremely limiting the clinical acceptability. Although numerous studies have demonstrated the feasibility of deep learning for the NICT enhancement in specific scenarios, their high data cost and limited generalizability have become large obstacles. The recent research on the foundation model has brought new opportunities for building a universal NICT enhancement model - bridging the image quality degradation with minimal data cost. However, owing to the challenges in the collection of large pre-training datasets and the compatibility of data variation, no success has been reported. In this paper, we propose a multi-scale integrated Transformer AMPlifier (TAMP), the first imaging foundation model for universal NICT enhancement. It has been pre-trained on a large-scale physical-driven simulation dataset with 3.6 million NICT-ICT image pairs, and is able to directly generalize to the NICT enhancement tasks with various non-ideal settings and body regions. Via the adaptation with few data, it can further achieve professional performance in real-world specific scenarios. Our extensive experiments have demonstrated that the proposed TAMP has significant potential for promoting the exploration and application of NICT and serving a wider range of medical scenarios.

Comprehensive quantification of cardiac structures from computed tomography (CT) remains limited not by data availability but by the scalability of measurements, which makes routine use impractical. Here we present a unified framework for comprehensive cardiac CT segmentation and phenotyping that combines a human-in-the-loop annotation pipeline, a cardiac CT augmentation technique, and a self-supervised foundation model pre-trained on 60,000 unlabeled cardiac CT scans. Using this approach, we assembled the largest and most comprehensive expert-annotated cardiac CT segmentation dataset to date, comprising 1598 cases and 14 distinct cardiac structures (1000 for training, 598 for the external test set). Across five external datasets, the framework segmented all structures more accurately and comprehensively than existing open-source tools. Self-supervised pre-training improved labeling efficiency, with the most significant gains observed during external evaluation in the low-data regime. Benchmarking across convolutional, transformer, and state-space architectures showed comparable performance, indicating that data quality and pre-training, rather than architecture, drove accuracy. The framework was scaled to population-level phenotyping, with segmented anatomy that carries functionally relevant information about ventricular function and disease severity beyond demographic variables. By openly releasing the largest dataset with human labels, code, model weights, a CT augmentation library, and software, this work provides a reproducible foundation for opportunistic cardiac phenotyping from routinely acquired CT scans.

We introduce MOMO, the first multi-sensor foundation model for Mars remote sensing. MOMO uses model merge to integrate representations learned independently from three key Martian sensors (HiRISE, CTX, and THEMIS), spanning resolutions from 0.25 m/pixel to 100 m/pixel. Central to our method is our novel Equal Validation Loss (EVL) strategy, which aligns checkpoints across sensors based on validation loss similarity before fusion via task arithmetic. This ensures models are merged at compatible convergence stages, leading to improved stability and generalization. We train MOMO on a large-scale, high-quality corpus of sim 12 million samples curated from Mars orbital data and evaluate it on 9 downstream tasks from Mars-Bench. MOMO achieves better overall performance compared to ImageNet pre-trained, earth observation foundation model, sensor-specific pre-training, and fully-supervised baselines. Particularly on segmentation tasks, MOMO shows consistent and significant performance improvement. Our results demonstrate that model merging through an optimal checkpoint selection strategy provides an effective approach for building foundation models for multi-resolution data. The model weights, pretraining code, pretraining data, and evaluation code are available at: https://github.com/kerner-lab/MOMO.

Foundation models like ChatGPT and GPT-4 have revolutionized artificial intelligence, exhibiting remarkable abilities to generalize across a wide array of tasks and applications beyond their initial training objectives. However, graph learning has predominantly focused on single-graph models, tailored to specific tasks or datasets, lacking the ability to transfer learned knowledge to different domains. This limitation stems from the inherent complexity and diversity of graph structures, along with the different feature and label spaces specific to graph data. In this paper, we recognize text as an effective unifying medium and employ Text-Attributed Graphs (TAGs) to leverage this potential. We present our UniGraph framework, designed to learn a foundation model for TAGs, which is capable of generalizing to unseen graphs and tasks across diverse domains. Unlike single-graph models that use pre-computed node features of varying dimensions as input, our approach leverages textual features for unifying node representations, even for graphs such as molecular graphs that do not naturally have textual features. We propose a novel cascaded architecture of Language Models (LMs) and Graph Neural Networks (GNNs) as backbone networks. Additionally, we propose the first pre-training algorithm specifically designed for large-scale self-supervised learning on TAGs, based on Masked Graph Modeling. We introduce graph instruction tuning using Large Language Models (LLMs) to enable zero-shot prediction ability. Our comprehensive experiments across various graph learning tasks and domains demonstrate the model's effectiveness in self-supervised representation learning on unseen graphs, few-shot in-context transfer, and zero-shot transfer, even surpassing or matching the performance of GNNs that have undergone supervised training on target datasets.

Medical vision-and-language pre-training (Med-VLP) has shown promising improvements on many downstream medical tasks owing to its applicability to extracting generic representations from medical images and texts. Practically, there exist two typical types, i.e., the fusion-encoder type and the dual-encoder type, depending on whether a heavy fusion module is used. The former is superior at multi-modal tasks owing to the sufficient interaction between modalities; the latter is good at uni-modal and cross-modal tasks due to the single-modality encoding ability. To take advantage of these two types, we propose an effective yet straightforward scheme named PTUnifier to unify the two types. We first unify the input format by introducing visual and textual prompts, which serve as a feature bank that stores the most representative images/texts. By doing so, a single model could serve as a foundation model that processes various tasks adopting different input formats (i.e., image-only, text-only, and image-text-pair). Furthermore, we construct a prompt pool (instead of static ones) to improve diversity and scalability. Experimental results show that our approach achieves state-of-the-art results on a broad range of tasks, spanning uni-modal tasks (i.e., image/text classification and text summarization), cross-modal tasks (i.e., image-to-text generation and image-text/text-image retrieval), and multi-modal tasks (i.e., visual question answering), demonstrating the effectiveness of our approach. Note that the adoption of prompts is orthogonal to most existing Med-VLP approaches and could be a beneficial and complementary extension to these approaches.

Developing generalizable ML-based solutions for disparate learning problems in network security is highly desired. However, despite a rich history of applying ML to network security, most existing solutions lack generalizability. This lack of progress can be attributed to an overreliance on supervised learning techniques and the associated challenges of curating well-specified labeled training data. This paper addresses a fundamental gap by introducing a novel transformer-based network foundation model, netFound. We employ self-supervised learning techniques on abundant, unlabeled network telemetry data for pre-training. This pretrained model can subsequently be fine-tuned to create generalizable learning artifacts for disparate learning tasks, even when using commonly available but challenging labeled datasets that are sparse, noisy, and skewed. To realize this goal, netFound leverages various domain-specific attributes and constraints unique to network data (packet traces) by developing multi-modal embeddings, protocol-aware tokenization, data-driven token composition, and hierarchical transformers. Our results demonstrate that netFound's domain-specific design choices ensure that it (1) effectively captures the hidden networking context in production settings, (2) outperforms four different SOTA methods on five different learning tasks, and (3) is robust to both noisy labels and learning shortcuts -- critical for developing generalizable ML models in practical settings.

Early detection, accurate segmentation, classification and tracking of polyps during colonoscopy are critical for preventing colorectal cancer. Many existing deep-learning-based methods for analyzing colonoscopic videos either require task-specific fine-tuning, lack tracking capabilities, or rely on domain-specific pre-training. In this paper, we introduce PolypSegTrack, a novel foundation model that jointly addresses polyp detection, segmentation, classification and unsupervised tracking in colonoscopic videos. Our approach leverages a novel conditional mask loss, enabling flexible training across datasets with either pixel-level segmentation masks or bounding box annotations, allowing us to bypass task-specific fine-tuning. Our unsupervised tracking module reliably associates polyp instances across frames using object queries, without relying on any heuristics. We leverage a robust vision foundation model backbone that is pre-trained unsupervisedly on natural images, thereby removing the need for domain-specific pre-training. Extensive experiments on multiple polyp benchmarks demonstrate that our method significantly outperforms existing state-of-the-art approaches in detection, segmentation, classification, and tracking.

Recent code large language models have achieved remarkable progress on general programming tasks. Nevertheless, their performance degrades significantly in industrial scenarios that require reasoning about hardware semantics, specialized language constructs, and strict resource constraints. To address these challenges, we introduce InCoder-32B (Industrial-Coder-32B), the first 32B-parameter code foundation model unifying code intelligence across chip design, GPU kernel optimization, embedded systems, compiler optimization, and 3D modeling. By adopting an efficient architecture, we train InCoder-32B from scratch with general code pre-training, curated industrial code annealing, mid-training that progressively extends context from 8K to 128K tokens with synthetic industrial reasoning data, and post-training with execution-grounded verification. We conduct extensive evaluation on 14 mainstream general code benchmarks and 9 industrial benchmarks spanning 4 specialized domains. Results show InCoder-32B achieves highly competitive performance on general tasks while establishing strong open-source baselines across industrial domains.

Despite recent scaling successes, multilingual ASR performance remains highly uneven, with long-tail languages suffering from severe data scarcity. This work addresses the challenge of building robust foundation models for underrepresented Central Asian languages (Kazakh, Kyrgyz, Uzbek). We present GigaAM Multilingual, a Conformer encoder pre-trained on 2M hours of audio using a HuBERT-style objective. Crucially, we introduce a cluster-level data balancing strategy during pre-training and a domain-aware sampling method during fine-tuning to mitigate head-language dominance. In controlled comparisons, our approach outperforms strong open pretrained encoders (Whisper Large v3, Omnilingual-1B) on target languages, achieving significant gains on spontaneous speech while maintaining efficiency. We release the foundation encoder and ASR model, offering a proven recipe for effective multilingual adaptation under realistic data imbalance.

Building scalable vision-language models to learn from diverse, multimodal data remains an open challenge. In this paper, we introduce an Efficient Vision-languagE foundation model, namely EVE, which is one unified multimodal Transformer pre-trained solely by one unified pre-training task. Specifically, EVE encodes both vision and language within a shared Transformer network integrated with modality-aware sparse Mixture-of-Experts (MoE) modules, which capture modality-specific information by selectively switching to different experts. To unify pre-training tasks of vision and language, EVE performs masked signal modeling on image-text pairs to reconstruct masked signals, i.e., image pixels and text tokens, given visible signals. This simple yet effective pre-training objective accelerates training by 3.5x compared to the model pre-trained with Image-Text Contrastive and Image-Text Matching losses. Owing to the combination of the unified architecture and pre-training task, EVE is easy to scale up, enabling better downstream performance with fewer resources and faster training speed. Despite its simplicity, EVE achieves state-of-the-art performance on various vision-language downstream tasks, including visual question answering, visual reasoning, and image-text retrieval.

Long-tailed learning has garnered increasing attention due to its practical significance. Among the various approaches, the fine-tuning paradigm has gained considerable interest with the advent of foundation models. However, most existing methods primarily focus on leveraging knowledge from these models, overlooking the inherent biases introduced by the imbalanced training data they rely on. In this paper, we examine how such imbalances from pre-training affect long-tailed downstream tasks. Specifically, we find the imbalance biases inherited in foundation models on downstream task as parameter imbalance and data imbalance. During fine-tuning, we observe that parameter imbalance plays a more critical role, while data imbalance can be mitigated using existing re-balancing strategies. Moreover, we find that parameter imbalance cannot be effectively addressed by current re-balancing techniques, such as adjusting the logits, during training, unlike data imbalance. To tackle both imbalances simultaneously, we build our method on causal learning and view the incomplete semantic factor as the confounder, which brings spurious correlations between input samples and labels. To resolve the negative effects of this, we propose a novel backdoor adjustment method that learns the true causal effect between input samples and labels, rather than merely fitting the correlations in the data. Notably, we achieve an average performance increase of about 1.67% on each dataset.

In this study, we aim to initiate the development of Radiology Foundation Model, termed as RadFM.We consider the construction of foundational models from the perspectives of data, model design, and evaluation thoroughly. Our contribution can be concluded as follows: (i), we construct a large-scale Medical Multi-modal Dataset, MedMD, consisting of 16M 2D and 3D medical scans. To the best of our knowledge, this is the first multi-modal dataset containing 3D medical scans. (ii), We propose an architecture that enables visually conditioned generative pre-training, allowing for the integration of text input interleaved with 2D or 3D medical scans to generate response for diverse radiologic tasks. The model was initially pre-trained on MedMD and subsequently domain-specific fine-tuned on RadMD, a radiologic cleaned version of MedMD, containing 3M radiologic visual-language pairs. (iii), we propose a new evaluation benchmark that comprises five tasks, aiming to comprehensively assess the capability of foundation models in handling practical clinical problems. Our experimental results confirm that RadFM significantly outperforms existing multi-modal foundation models. The codes, data, and model checkpoint will all be made publicly available to promote further research and development in the field.

River systems operate as inherently interconnected continuous networks, meaning river hydrodynamic simulation ought to be a systemic process. However, widespread hydrology data scarcity often restricts data-driven forecasting to isolated predictions. To achieve systemic simulation and reduce reliance on river observations, we present GraphRiverCast (GRC), a topology-informed AI foundation model designed to simulate multivariate river hydrodynamics in global river systems. GRC is capable of operating in a "ColdStart" mode, generating predictions without relying on historical river states for initialization. In 7-day global pseudo-hindcasts, GRC-ColdStart functions as a robust standalone simulator, achieving a Nash-Sutcliffe Efficiency (NSE) of approximately 0.82 without exhibiting the significant error accumulation typical of autoregressive paradigms. Ablation studies reveal that topological encoding serves as indispensable structural information in the absence of historical states, explicitly guiding hydraulic connectivity and network-scale mass redistribution to reconstruct flow dynamics. Furthermore, when adapted locally via a pre-training and fine-tuning strategy, GRC consistently outperforms physics-based and locally-trained AI baselines. Crucially, this superiority extends from gauged reaches to full river networks, underscoring the necessity of topology encoding and physics-based pre-training. Built on a physics-aligned neural operator architecture, GRC enables rapid and cross-scale adaptive simulation, establishing a collaborative paradigm bridging global hydrodynamic knowledge with local hydrological reality.

Outlier detection (OD) has a vast literature as it finds numerous real-world applications. Being an unsupervised task, model selection is a key bottleneck for OD without label supervision. Despite a long list of available OD algorithms with tunable hyperparameters, the lack of systematic approaches for unsupervised algorithm and hyperparameter selection limits their effective use in practice. In this paper, we present FoMo-0D, a pre-trained Foundation Model for zero/0-shot OD on tabular data, which bypasses the hurdle of model selection altogether. Having been pre-trained on synthetic data, FoMo-0D can directly predict the (outlier/inlier) label of test samples without parameter fine-tuning -- requiring no labeled data, and no additional training or hyperparameter tuning when given a new task. Extensive experiments on 57 real-world datasets against 26 baselines show that FoMo-0D is highly competitive; outperforming the majority of the baselines with no statistically significant difference from the 2nd best method. Further, FoMo-0D is efficient in inference time requiring only 7.7 ms per sample on average, with at least 7x speed-up compared to previous methods. To facilitate future research, our implementations for data synthesis and pre-training as well as model checkpoints are openly available at https://github.com/A-Chicharito-S/FoMo-0D.

With the growth of high-quality data and advancement in visual pre-training paradigms, Video Foundation Models (VFMs) have made significant progress recently, demonstrating their remarkable performance on traditional video understanding benchmarks. However, the existing benchmarks (e.g. Kinetics) and their evaluation protocols are often limited by relatively poor diversity, high evaluation costs, and saturated performance metrics. In this paper, we build a comprehensive benchmark suite to address these issues, namely VideoEval. Specifically, we establish the Video Task Adaption Benchmark (VidTAB) and the Video Embedding Benchmark (VidEB) from two perspectives: evaluating the task adaptability of VFMs under few-shot conditions and assessing their representation power by directly applying to downstream tasks. With VideoEval, we conduct a large-scale study on 20 popular open-source vision foundation models. Our study reveals some insightful findings on VFMs: 1) overall, current VFMs exhibit weak generalization across diverse tasks, 2) increasing video data, whether labeled or weakly-labeled video-text pairs, does not necessarily improve task performance, 3) the effectiveness of some pre-training paradigms may not be fully validated in previous benchmarks, and 4) combining different pre-training paradigms can help improve the generalization capabilities. We believe this study serves as an important complement to the current evaluation for VFMs and offers valuable insights for the future research.

Embodied AI is a crucial frontier in robotics, capable of planning and executing action sequences for robots to accomplish long-horizon tasks in physical environments. In this work, we introduce EmbodiedGPT, an end-to-end multi-modal foundation model for embodied AI, empowering embodied agents with multi-modal understanding and execution capabilities. To achieve this, we have made the following efforts: (i) We craft a large-scale embodied planning dataset, termed EgoCOT. The dataset consists of carefully selected videos from the Ego4D dataset, along with corresponding high-quality language instructions. Specifically, we generate a sequence of sub-goals with the "Chain of Thoughts" mode for effective embodied planning. (ii) We introduce an efficient training approach to EmbodiedGPT for high-quality plan generation, by adapting a 7B large language model (LLM) to the EgoCOT dataset via prefix tuning. (iii) We introduce a paradigm for extracting task-related features from LLM-generated planning queries to form a closed loop between high-level planning and low-level control. Extensive experiments show the effectiveness of EmbodiedGPT on embodied tasks, including embodied planning, embodied control, visual captioning, and visual question answering. Notably, EmbodiedGPT significantly enhances the success rate of the embodied control task by extracting more effective features. It has achieved a remarkable 1.6 times increase in success rate on the Franka Kitchen benchmark and a 1.3 times increase on the Meta-World benchmark, compared to the BLIP-2 baseline fine-tuned with the Ego4D dataset.

We present Oxygen-TryOn, a unified foundation model for any-item virtual try-on. Rather than repurposing a general-purpose image editor, Oxygen-TryOn is fashion-native, built for try-on through a dedicated data engine and try-on-specific training. Given one or more reference items (clean product shots or in-the-wild worn-on photos) and a single target subject image, it synthesizes a photorealistic image of the subject wearing the items across virtually any fashion category. Prior systems handle a single garment category in a studio setting, and recent multi-reference methods remain garment-centric; in contrast, Oxygen-TryOn supports diverse items and scenarios, including full- and half-body views, a variable number of references, and free multi-item composition, while faithfully preserving both subject identity and item appearance. Instead of mask-based inpainting, we reformulate try-on as a multi-reference, understanding-driven generation task. We build a data engine that collects, manufactures, annotates, and filters high-quality try-on data at scale, and design a three-stage recipe of continued pre-training (CPT), supervised fine-tuning (SFT), and reinforcement learning (RL). The RL stage uses a hybrid reward combining an in-house try-on reward model with a proprietary, rubric-guided general-purpose model, jointly supervising fine-grained consistency and instruction-level quality. It also follows general editing instructions (e.g., pose changes) in the same pass. Across public benchmarks and our in-house Oxygen-TryOn Bench, it achieves state-of-the-art consistency and realism on single-item try-on and leads on multi-item try-on, matching or surpassing both leading proprietary systems (Nano Banana Pro, GPT-Image-2, Seedream5 Lite) and open-source models (FLUX.2).

Foundation models have demonstrated remarkable success across various scientific domains, motivating our exploration of their potential in solar physics. In this paper, we present Solaris, the first foundation model for forecasting the Sun's atmosphere. We leverage 13 years of full-disk, multi-wavelength solar imagery from the Solar Dynamics Observatory, spanning a complete solar cycle, to pre-train Solaris for 12-hour interval forecasting. Solaris is built on a large-scale 3D Swin Transformer architecture with 109 million parameters. We demonstrate Solaris' ability to generalize by fine-tuning on a low-data regime using a single wavelength (1700 {\AA}), that was not included in pre-training, outperforming models trained from scratch on this specific wavelength. Our results indicate that Solaris can effectively capture the complex dynamics of the solar atmosphere and transform solar forecasting.

Parameter-efficient fine-tuning (PEFT) techniques such as low-rank adaptation (LoRA) can effectively adapt large pre-trained foundation models to downstream tasks using only a small fraction (0.1%-10%) of the original trainable weights. An under-explored question of PEFT is in extending the pre-training phase without supervised labels; that is, can we adapt a pre-trained foundation model to a new domain via efficient self-supervised pre-training on this domain? In this work, we introduce ExPLoRA, a highly effective technique to improve transfer learning of pre-trained vision transformers (ViTs) under domain shifts. Initializing a ViT with pre-trained weights on large, natural-image datasets such as from DinoV2 or MAE, ExPLoRA continues the unsupervised pre-training objective on a new domain, unfreezing 1-2 pre-trained ViT blocks and tuning all other layers with LoRA. We then fine-tune the resulting model only with LoRA on this new domain for supervised learning. Our experiments demonstrate state-of-the-art results on satellite imagery, even outperforming fully pre-training and fine-tuning ViTs. Using the DinoV2 training objective, we demonstrate up to 8% improvement in linear probing top-1 accuracy on downstream tasks while using <10% of the number of parameters that are used in prior fully-tuned state-of-the art approaches. Our ablation studies confirm the efficacy of our approach over other baselines such as PEFT. Code is available on the project website: https://samar-khanna.github.io/ExPLoRA/

Channel prediction permits to acquire channel state information (CSI) without signaling overhead. However, almost all existing channel prediction methods necessitate the deployment of a dedicated model to accommodate a specific configuration. Leveraging the powerful modeling and multi-task learning capabilities of foundation models, we propose the first space-time-frequency (STF) wireless foundation model (WiFo) to address time-frequency channel prediction tasks in a one-for-all manner. Specifically, WiFo is initially pre-trained over massive and extensive diverse CSI datasets. Then, the model will be instantly used for channel prediction under various CSI configurations without any fine-tuning. We propose a masked autoencoder (MAE)-based network structure for WiFo to handle heterogeneous STF CSI data, and design several mask reconstruction tasks for self-supervised pre-training to capture the inherent 3D variations of CSI. To fully unleash its predictive power, we build a large-scale heterogeneous simulated CSI dataset consisting of 160K CSI samples for pre-training. Simulations validate its superior unified learning performance across multiple datasets and demonstrate its state-of-the-art (SOTA) zero-shot generalization performance via comparisons with other full-shot baselines.

Accurate hyperspectral image (HSI) interpretation is critical for providing valuable insights into various earth observation-related applications such as urban planning, precision agriculture, and environmental monitoring. However, existing HSI processing methods are predominantly task-specific and scene-dependent, which severely limits their ability to transfer knowledge across tasks and scenes, thereby reducing the practicality in real-world applications. To address these challenges, we present HyperSIGMA, a vision transformer-based foundation model that unifies HSI interpretation across tasks and scenes, scalable to over one billion parameters. To overcome the spectral and spatial redundancy inherent in HSIs, we introduce a novel sparse sampling attention (SSA) mechanism, which effectively promotes the learning of diverse contextual features and serves as the basic block of HyperSIGMA. HyperSIGMA integrates spatial and spectral features using a specially designed spectral enhancement module. In addition, we construct a large-scale hyperspectral dataset, HyperGlobal-450K, for pre-training, which contains about 450K hyperspectral images, significantly surpassing existing datasets in scale. Extensive experiments on various high-level and low-level HSI tasks demonstrate HyperSIGMA's versatility and superior representational capability compared to current state-of-the-art methods. Moreover, HyperSIGMA shows significant advantages in scalability, robustness, cross-modal transferring capability, real-world applicability, and computational efficiency. The code and models will be released at https://github.com/WHU-Sigma/HyperSIGMA.

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the level of one or more whole slide images, and foundation models to date, which process the thousands of image tiles contained in a whole slide image separately. The requirement to train a network to aggregate information across a large number of tiles in multiple whole slide images limits these models' impact. In this work, we present a slide-level foundation model for H&E-stained histopathology, PRISM, that builds on Virchow tile embeddings and leverages clinical report text for pre-training. Using the tile embeddings, PRISM produces slide-level embeddings with the ability to generate clinical reports, resulting in several modes of use. Using text prompts, PRISM achieves zero-shot cancer detection and sub-typing performance approaching and surpassing that of a supervised aggregator model. Using the slide embeddings with linear classifiers, PRISM surpasses supervised aggregator models. Furthermore, we demonstrate that fine-tuning of the PRISM slide encoder yields label-efficient training for biomarker prediction, a task that typically suffers from low availability of training data; an aggregator initialized with PRISM and trained on as little as 10% of the training data can outperform a supervised baseline that uses all of the data.

To handle the scarcity and heterogeneity of electroencephalography (EEG) data for Brain-Computer Interface (BCI) tasks, and to harness the power of large publicly available data sets, we propose Neuro-GPT, a foundation model consisting of an EEG encoder and a GPT model. The foundation model is pre-trained on a large-scale data set using a self-supervised task that learns how to reconstruct masked EEG segments. We then fine-tune the model on a Motor Imagery Classification task to validate its performance in a low-data regime (9 subjects). Our experiments demonstrate that applying a foundation model can significantly improve classification performance compared to a model trained from scratch, which provides evidence for the generalizability of the foundation model and its ability to address challenges of data scarcity and heterogeneity in EEG. The code is publicly available at github.com/wenhui0206/NeuroGPT.

The recent success of large foundation models in artificial intelligence has prompted the emergence of chemical pre-trained models. Despite the growing interest in large molecular pre-trained models that provide informative representations for downstream tasks, attempts for multimodal pre-training approaches on the molecule domain were limited. To address this, we present a novel multimodal molecular pre-trained model that incorporates the modalities of structure and biochemical properties, drawing inspiration from recent advances in multimodal learning techniques. Our proposed model pipeline of data handling and training objectives aligns the structure/property features in a common embedding space, which enables the model to regard bidirectional information between the molecules' structure and properties. These contributions emerge synergistic knowledge, allowing us to tackle both multimodal and unimodal downstream tasks through a single model. Through extensive experiments, we demonstrate that our model shows remarkable capabilities in solving various meaningful chemical challenges, including conditional molecule generation, property prediction, molecule classification, and reaction prediction.

To explore the limit of dialogue generation pre-training, we present the models of PLATO-XL with up to 11 billion parameters, trained on both Chinese and English social media conversations. To train such large models, we adopt the architecture of unified transformer with high computation and parameter efficiency. In addition, we carry out multi-party aware pre-training to better distinguish the characteristic information in social media conversations. With such designs, PLATO-XL successfully achieves superior performances as compared to other approaches in both Chinese and English chitchat. We further explore the capacity of PLATO-XL on other conversational tasks, such as knowledge grounded dialogue and task-oriented conversation. The experimental results indicate that PLATO-XL obtains state-of-the-art results across multiple conversational tasks, verifying its potential as a foundation model of conversational AI.

Decoding the linguistic intricacies of the genome is a crucial problem in biology, and pre-trained foundational models such as DNABERT and Nucleotide Transformer have made significant strides in this area. Existing works have largely hinged on k-mer, fixed-length permutations of A, T, C, and G, as the token of the genome language due to its simplicity. However, we argue that the computation and sample inefficiencies introduced by k-mer tokenization are primary obstacles in developing large genome foundational models. We provide conceptual and empirical insights into genome tokenization, building on which we propose to replace k-mer tokenization with Byte Pair Encoding (BPE), a statistics-based data compression algorithm that constructs tokens by iteratively merging the most frequent co-occurring genome segment in the corpus. We demonstrate that BPE not only overcomes the limitations of k-mer tokenization but also benefits from the computational efficiency of non-overlapping tokenization. Based on these insights, we introduce DNABERT-2, a refined genome foundation model that adapts an efficient tokenizer and employs multiple strategies to overcome input length constraints, reduce time and memory expenditure, and enhance model capability. Furthermore, we identify the absence of a comprehensive and standardized benchmark for genome understanding as another significant impediment to fair comparative analysis. In response, we propose the Genome Understanding Evaluation (GUE), a comprehensive multi-species genome classification dataset that amalgamates 28 distinct datasets across 7 tasks, with input lengths ranging from 70 to 1000. Through comprehensive experiments on the GUE benchmark, we demonstrate that DNABERT-2 achieves comparable performance to the state-of-the-art model with 21 times fewer parameters and approximately 56 times less GPU time in pre-training.

With the rapid deployment of SCADA systems, how to effectively analyze industrial signals and detect abnormal states is an urgent need for the industry. Due to the significant heterogeneity of these signals, which we summarize as the M5 problem, previous works only focus on small sub-problems and employ specialized models, failing to utilize the synergies between modalities and the powerful scaling law. However, we argue that the M5 signals can be modeled in a unified manner due to the intrinsic similarity. As a result, we propose FISHER, a Foundation model for multi-modal Industrial Signal compreHEnsive Representation. To support arbitrary sampling rates, FISHER considers the increment of sampling rate as the concatenation of sub-band information. Specifically, FISHER takes the STFT sub-band as the modeling unit and adopts a teacher student SSL framework for pre-training. We also develop the RMIS benchmark, which evaluates the representations of M5 industrial signals on multiple health management tasks. Compared with top SSL models, FISHER showcases versatile and outstanding capabilities with a general performance gain up to 5.03%, along with much more efficient scaling curves. We also investigate the scaling law on downstream tasks and derive potential avenues for future works. FISHER is now open-sourced on https://github.com/jianganbai/FISHER

Time series forecasting plays a crucial role in data mining, driving rapid advancements across numerous industries. With the emergence of large models, time series foundation models (TSFMs) have exhibited remarkable generalization capabilities, such as zero-shot learning, through large-scale pre-training. Meanwhile, Retrieval-Augmented Generation (RAG) methods have been widely employed to enhance the performance of foundation models on unseen data, allowing models to access to external knowledge. In this paper, we introduce TimeRAF, a Retrieval-Augmented Forecasting model that enhance zero-shot time series forecasting through retrieval-augmented techniques. We develop customized time series knowledge bases that are tailored to the specific forecasting tasks. TimeRAF employs an end-to-end learnable retriever to extract valuable information from the knowledge base. Additionally, we propose Channel Prompting for knowledge integration, which effectively extracts relevant information from the retrieved knowledge along the channel dimension. Extensive experiments demonstrate the effectiveness of our model, showing significant improvement across various domains and datasets.

Checkpointing to preserve training states is crucial during the development of Large Foundation Models (LFMs), for training resumption upon various failures or changes in GPU resources and parallelism configurations. In addition, saved checkpoints are dispatched to evaluation tasks or transferred across different training stages (e.g., from pre-training to post-training). All these scenarios require resharding distributed checkpoints from one parallelism to another. In production environments, different LFMs are trained with various frameworks and storage backends, depending on model sizes and training scales. A high-performance checkpointing system is needed to enable efficient checkpoint management at scale throughout the lifecycle of LFM development. We introduce ByteCheckpoint, an industrial-grade checkpointing system for large-scale LFM training. ByteCheckpoint features: a parallelism-agnostic checkpoint representation that enables efficient load-time checkpoint resharding; a generic checkpoint saving/loading workflow to accommodate multiple training frameworks and support different storage backends; full-stack optimizations to ensure high I/O efficiency and scalability; a suite of monitoring tools to streamline large-scale performance analysis and bottleneck detection. Compared to existing open-source checkpointing systems [52, 58], ByteCheckpoint significantly reduces runtime checkpoint stalls, achieving an average reduction of 54.20x. For saving and loading times, ByteCheckpoint achieves improvements of up to 9.96x and 8.80x, respectively.

In this technical report, we present Skywork-13B, a family of large language models (LLMs) trained on a corpus of over 3.2 trillion tokens drawn from both English and Chinese texts. This bilingual foundation model is the most extensively trained and openly published LLMs of comparable size to date. We introduce a two-stage training methodology using a segmented corpus, targeting general purpose training and then domain-specific enhancement training, respectively. We show that our model not only excels on popular benchmarks, but also achieves state of the art performance in Chinese language modeling on diverse domains. Furthermore, we propose a novel leakage detection method, demonstrating that test data contamination is a pressing issue warranting further investigation by the LLM community. To spur future research, we release Skywork-13B along with checkpoints obtained during intermediate stages of the training process. We are also releasing part of our SkyPile corpus, a collection of over 150 billion tokens of web text, which is the largest high quality open Chinese pre-training corpus to date. We hope Skywork-13B and our open corpus will serve as a valuable open-source resource to democratize access to high-quality LLMs.

Graph Foundation Models (GFMs) have emerged as a promising paradigm for learning transferable representations across diverse graph domains. Recent advancements in GFMs have been largely dominated by two paradigms: Graph Neural Network and Large Language Model (LLM) based methods. However, these methods often face a fundamental dilemma between training with limited data and a heavy reliance on textual attributes. Tabular foundation models (TFMs) offer a potential alternative, as node features and representations can be naturally organized in a tabular form. However, how to enable TFMs to effectively capture structural information of graphs remains largely unexplored. The key challenge is to learn a graph-to-table alignment mechanism that enables graph structural understanding for TFMs. To address this, we propose GTAlign, a surprisingly simple yet effective Graph-to-Table Alignment framework for text-free Graph Foundation Model. Specifically, we first pretrain a graph encoder that maps diverse graphs into a unified latent space to capture domain-agnostic graph representations. To further bridge the gap between graph topology and the tabular representation space, we propose community-guided continual pre-training, where pseudo-labels derived from graph community are used to construct few-shot prediction episodes. Lastly, we adapt the graph encoder for an unseen target domain and perform in-context inference. Extensive experiments on five benchmark datasets demonstrate that GTAlign significantly outperforms state-of-the-art baselines on both node and graph classification, offering a simple, effective, and text-free GFM model. Code will be released upon acceptance.

Recent foundation image and video generation models offer strong generalization and controllability, but their direct application to embodied scenarios is limited by requirements for multi-view consistency, geometric coherence, and robot embodiment constraints. Existing methods typically adapt foundation models with limited robot data, often sacrificing visual knowledge acquired during large-scale pre-training. We present Xiaomi-Robotics-U0, a 38-billion-parameter multimodal autoregressive model for unified embodied synthesis. It treats embodied generation as an extension of foundation image and video generation and jointly optimizes text-to-image generation, image editing, embodied scene generation, embodied transfer, and embodied video generation. This unified framework preserves the generalization of the pre-trained world foundation model while adapting it to embodied settings. Xiaomi-Robotics-U0 is the first model to support high-quality multi-view scene generation across multiple robot embodiments and to introduce structured, controllable embodied transfer for fine-grained editing while preserving multi-view consistency and interaction dynamics. It achieves state-of-the-art results on single-step and sequential generation tasks, outperforming GPT-Image-2.0 in human evaluations of embodied scene generation and transfer, ranking first on World Arena for embodied video generation, and improving the out-of-distribution success rate of pi_0.5 from 36.9% to 63.2% on challenging real-world manipulation tasks. These results show that foundation world models can serve both as embodied world models and scalable data engines for embodied intelligence. Code and checkpoints are available at https://robotics.xiaomi.com/xiaomi-robotics-u0.html.

In this report, we present LOGOS (Language Of Generative Objects in Science), a scientific generative language model that unifies heterogeneous tasks across the natural sciences within a single autoregressive framework based on a shared scientific grammar. It encodes diverse scientific objects and their spatial interactions as token sequences over a common vocabulary. By representing spatial contact and constraint patterns as discrete tokens, the model captures complex structural interactions in a purely sequential manner, without relying on explicit coordinates or geometric neural networks. This unified representation enables a wide range of downstream tasks to be formulated consistently as next-token prediction in the same grammar space, creating strong alignment between continued multi-domain pre-training and downstream objectives. Across diverse tasks, LOGOS consistently matches or outperforms domain-specific baselines, providing preliminary evidence for the feasibility of "one model fits all" in the natural sciences. We train LOGOS models at different scales (1B, 3B, and 8B parameters) and find a consistent positive correlation between model size and performance. This suggests that the future of AI for Science (AI4S) may not lie in building an independent technical stack that is separated from large language models (LLMs). Instead, it may depend on deeply aligning scientific foundation models with LLMs through shared architectures, shared training paradigms, and shared inference infrastructure, so that LLMs can truly become a new entry point for AI4S. We release the model weights and associated resources to facilitate further research.

In recent years, foundation models (FMs) such as large language models (LLMs) and latent diffusion models (LDMs) have profoundly impacted diverse sectors, including music. This comprehensive review examines state-of-the-art (SOTA) pre-trained models and foundation models in music, spanning from representation learning, generative learning and multimodal learning. We first contextualise the significance of music in various industries and trace the evolution of AI in music. By delineating the modalities targeted by foundation models, we discover many of the music representations are underexplored in FM development. Then, emphasis is placed on the lack of versatility of previous methods on diverse music applications, along with the potential of FMs in music understanding, generation and medical application. By comprehensively exploring the details of the model pre-training paradigm, architectural choices, tokenisation, finetuning methodologies and controllability, we emphasise the important topics that should have been well explored, like instruction tuning and in-context learning, scaling law and emergent ability, as well as long-sequence modelling etc. A dedicated section presents insights into music agents, accompanied by a thorough analysis of datasets and evaluations essential for pre-training and downstream tasks. Finally, by underscoring the vital importance of ethical considerations, we advocate that following research on FM for music should focus more on such issues as interpretability, transparency, human responsibility, and copyright issues. The paper offers insights into future challenges and trends on FMs for music, aiming to shape the trajectory of human-AI collaboration in the music realm.

Machine learning models in astrophysics are often limited in scope and cannot adapt to data from new instruments or tasks. We introduce SpectraFM, a Transformer-based foundation model architecture that can be pre-trained on stellar spectra from any wavelength range and instrument. SpectraFM excels in generalization by combining flexibility with knowledge transfer from pre-training, allowing it to outperform traditional machine learning methods, especially in scenarios with limited training data. Our model is pre-trained on approximately 90k examples of synthetic spectra to predict the chemical abundances (Fe, Mg, O), temperature, and specific gravity of stars. We then fine-tune the model on real spectra to adapt it to observational data before fine-tuning it further on a restricted 100-star training set in a different wavelength range to predict iron abundance. Despite a small iron-rich training set of real spectra, transfer learning from the synthetic spectra pre-training enables the model to perform well on iron-poor stars. In contrast, a neural network trained from scratch fails at this task. We investigate the Transformer attention mechanism and find that the wavelengths receiving attention carry physical information about chemical composition. By leveraging the knowledge from pre-training and its ability to handle non-spectra inputs, SpectraFM reduces the need for large training datasets and enables cross-instrument and cross-domain research. Its adaptability makes it well-suited for tackling emerging challenges in astrophysics, like extracting insights from multi-modal datasets.

Multi-domain graph pre-training integrates knowledge from diverse domains to enhance performance in the target domains, which is crucial for building graph foundation models. Despite initial success, existing solutions often fall short of answering a fundamental question: how is knowledge integrated or transferred across domains? This theoretical limitation motivates us to rethink the consistency and transferability between model pre-training and domain adaptation. In this paper, we propose a fresh Riemannian geometry perspective, whose core idea is to merge any graph dataset into a unified, smooth Riemannian manifold, enabling a systematic understanding of knowledge integration and transfer. To achieve this, our key contribution is the theoretical establishment of neural manifold gluing, which first characterizes local geometry using an adaptive orthogonal frame and then "glues" the local pieces together into a coherent whole. Building on this theory, we present the GraphGlue framework, which supports batched pre-training with EMA prototyping and provides a transferability measure based on geometric consistence. Extensive experiments demonstrate its superior performance across diverse graph domains. Moreover, we empirically validated GraphGlue's geometric scaling law, showing that larger quantities of datasets improve model transferability by producing a smoother manifold. Codes are available at https://github.com/RiemannGraph/GraphGlue.

Context: Automated code generation using Foundation Models (FMs) offers promising solutions for enhancing software development efficiency. However, challenges remain in ensuring domain specificity, cost-effectiveness, and security - especially when relying on third-party APIs. This paper introduces CodeLSI, a framework that combines low-rank optimization and domain-specific instruction tuning to address these challenges. Objectives: The aim of this study is to develop and evaluate CodeLSI, a novel approach for generating high-quality code tailored to specific domains, using FMs fine-tuned on company infrastructure without dependence on external APIs. Methods: CodeLSI applies low-rank adaptation techniques to reduce the computational cost of model pre-training and fine-tuning. Domain-specific instruction tuning is employed to align code generation with organizational needs. We implemented and tested the framework on real-world JavaScript coding tasks using datasets drawn from internal software projects. Results: Experimental evaluations show that CodeLSI produces high-quality, context aware code. It outperforms baseline models in terms of relevance, accuracy, and domain fit. The use of low-rank optimization significantly reduced resource requirements, enabling scalable training on company-owned infrastructure. Conclusion: CodeLSI demonstrates that combining low-rank optimization with domain specific tuning can enhance the practicality and performance of FMs for automated code generation. This approach provides a secure, cost-efficient alternative to commercial API based solutions and supports faster, more targeted innovation in software development.

The distributed training of foundation models, particularly large language models (LLMs), demands a high level of communication. Consequently, it is highly dependent on a centralized cluster with fast and reliable interconnects. Can we conduct training on slow networks and thereby unleash the power of decentralized clusters when dealing with models exceeding 100 billion parameters? In this paper, we propose DiLoCoX, a low-communication large-scale decentralized cluster training framework. It combines Pipeline Parallelism with Dual Optimizer Policy, One-Step-Delay Overlap of Communication and Local Training, and an Adaptive Gradient Compression Scheme. This combination significantly improves the scale of parameters and the speed of model pre-training. We justify the benefits of one-step-delay overlap of communication and local training, as well as the adaptive gradient compression scheme, through a theoretical analysis of convergence. Empirically, we demonstrate that DiLoCoX is capable of pre-training a 107B foundation model over a 1Gbps network. Compared to vanilla AllReduce, DiLoCoX can achieve a 357x speedup in distributed training while maintaining negligible degradation in model convergence. To the best of our knowledge, this is the first decentralized training framework successfully applied to models with over 100 billion parameters.

Recent breakthroughs in self-supervised learning have enabled the use of large unlabeled datasets to train visual foundation models that can generalize to a variety of downstream tasks. While this training paradigm is well suited for the medical domain where annotations are scarce, large-scale pre-training in the medical domain, and in particular pathology, has not been extensively studied. Previous work in self-supervised learning in pathology has leveraged smaller datasets for both pre-training and evaluating downstream performance. The aim of this project is to train the largest academic foundation model and benchmark the most prominent self-supervised learning algorithms by pre-training and evaluating downstream performance on large clinical pathology datasets. We collected the largest pathology dataset to date, consisting of over 3 billion images from over 423 thousand microscopy slides. We compared pre-training of visual transformer models using the masked autoencoder (MAE) and DINO algorithms. We evaluated performance on six clinically relevant tasks from three anatomic sites and two institutions: breast cancer detection, inflammatory bowel disease detection, breast cancer estrogen receptor prediction, lung adenocarcinoma EGFR mutation prediction, and lung cancer immunotherapy response prediction. Our results demonstrate that pre-training on pathology data is beneficial for downstream performance compared to pre-training on natural images. Additionally, the DINO algorithm achieved better generalization performance across all tasks tested. The presented results signify a phase change in computational pathology research, paving the way into a new era of more performant models based on large-scale, parallel pre-training at the billion-image scale.

Time series anomaly detection (TSAD) is a critical task, but developing models that generalize to unseen data in a zero-shot manner remains a major challenge. Prevailing foundation models for TSAD predominantly rely on reconstruction-based objectives, which suffer from a fundamental objective mismatch: they struggle to identify subtle anomalies while often misinterpreting complex normal patterns, leading to high rates of false negatives and positives. To overcome these limitations, we introduce TimeRCD, a novel foundation model for TSAD built upon a new pre-training paradigm: Relative Context Discrepancy (RCD). Instead of learning to reconstruct inputs, TimeRCD is explicitly trained to identify anomalies by detecting significant discrepancies between adjacent time windows. This relational approach, implemented with a standard Transformer architecture, enables the model to capture contextual shifts indicative of anomalies that reconstruction-based methods often miss. To facilitate this paradigm, we develop a large-scale, diverse synthetic corpus with token-level anomaly labels, providing the rich supervisory signal necessary for effective pre-training. Extensive experiments demonstrate that TimeRCD significantly outperforms existing general-purpose and anomaly-specific foundation models in zero-shot TSAD across diverse datasets. Our results validate the superiority of the RCD paradigm and establish a new, effective path toward building robust and generalizable foundation models for time series anomaly detection.

The advent of foundation models (FMs) as an emerging suite of AI techniques has struck a wave of opportunities in computational healthcare. The interactive nature of these models, guided by pre-training data and human instructions, has ignited a data-centric AI paradigm that emphasizes better data characterization, quality, and scale. In healthcare AI, obtaining and processing high-quality clinical data records has been a longstanding challenge, ranging from data quantity, annotation, patient privacy, and ethics. In this survey, we investigate a wide range of data-centric approaches in the FM era (from model pre-training to inference) towards improving the healthcare workflow. We discuss key perspectives in AI security, assessment, and alignment with human values. Finally, we offer a promising outlook of FM-based analytics to enhance the performance of patient outcome and clinical workflow in the evolving landscape of healthcare and medicine. We provide an up-to-date list of healthcare-related foundation models and datasets at https://github.com/Yunkun-Zhang/Data-Centric-FM-Healthcare .

Retinal foundation models aim to learn generalizable representations from diverse retinal images, facilitating label-efficient model adaptation across various ophthalmic tasks. Despite their success, current retinal foundation models are generally restricted to a single imaging modality, such as Color Fundus Photography (CFP) or Optical Coherence Tomography (OCT), limiting their versatility. Moreover, these models may struggle to fully leverage expert annotations and overlook the valuable domain knowledge essential for domain-specific representation learning. To overcome these limitations, we introduce UrFound, a retinal foundation model designed to learn universal representations from both multimodal retinal images and domain knowledge. UrFound is equipped with a modality-agnostic image encoder and accepts either CFP or OCT images as inputs. To integrate domain knowledge into representation learning, we encode expert annotation in text supervision and propose a knowledge-guided masked modeling strategy for model pre-training. It involves reconstructing randomly masked patches of retinal images while predicting masked text tokens conditioned on the corresponding retinal image. This approach aligns multimodal images and textual expert annotations within a unified latent space, facilitating generalizable and domain-specific representation learning. Experimental results demonstrate that UrFound exhibits strong generalization ability and data efficiency when adapting to various tasks in retinal image analysis. By training on ~180k retinal images, UrFound significantly outperforms the state-of-the-art retinal foundation model trained on up to 1.6 million unlabelled images across 8 public retinal datasets. Our code and data are available at https://github.com/yukkai/UrFound.

We present Mach-Mind-4-Flash, a 35B-parameter Mixture-of-Experts (MoE) agentic model with 3B activated parameters. Through post-training optimization alone without scaling pre-training compute, the model achieves performance on par with or surpassing that of 100B-parameter-class models. By introducing scalable agentic interaction environments for large-scale reinforcement learning, the model attains significant performance gains on real-world application tasks. Our pipeline comprises three stages: (1) a unified RL/OPD training infrastructure with dynamic multi-teacher scheduling and operator-level acceleration, delivering 17\% end-to-end training speedup; (2) multiple domain-specific RL experts trained in parallel across Reasoning, General, and Agent tracks, then fused into a single generalist via Multi-Teacher On-Policy Distillation (MOPD) -- a routed reverse-KL objective that eliminates the see-saw degradation of mixed-reward RL; (3) Hybrid Median-length Policy Optimization (HMPO), a single-stage token-efficiency method that compresses reasoning chains by 19--46\% with le0.7 percentage-point accuracy loss. Mach-Mind-4-Flash scores 92.70 on AIME'26, 82.82 on IFBench, 80.74 on Behavioral-SafetyBench, 75.80 on BFCL-v4, 72.31 on BrowseComp-zh, and 84.20 on ClawBench -- leading or matching models with 10--30times its activated size at a fraction of the inference cost.

Contrastive Language-Image Pre-training (CLIP) has become a foundation model and has been applied to various vision and multimodal tasks. However, recent works indicate that CLIP falls short in distinguishing detailed differences in images and shows suboptimal performance on dense-prediction and vision-centric multimodal tasks. Therefore, this work focuses on improving existing CLIP models, aiming to capture as many visual details in images as possible. We find that a specific type of generative models, unCLIP, provides a suitable framework for achieving our goal. Specifically, unCLIP trains an image generator conditioned on the CLIP image embedding. In other words, it inverts the CLIP image encoder. Compared to discriminative models like CLIP, generative models are better at capturing image details because they are trained to learn the data distribution of images. Additionally, the conditional input space of unCLIP aligns with CLIP's original image-text embedding space. Therefore, we propose to invert unCLIP (dubbed un^2CLIP) to improve the CLIP model. In this way, the improved image encoder can gain unCLIP's visual detail capturing ability while preserving its alignment with the original text encoder simultaneously. We evaluate our improved CLIP across various tasks to which CLIP has been applied, including the challenging MMVP-VLM benchmark, the dense-prediction open-vocabulary segmentation task, and multimodal large language model tasks. Experiments show that un^2CLIP significantly improves the original CLIP and previous CLIP improvement methods. Code and models will be available at https://github.com/LiYinqi/un2CLIP.

We present a scientific reasoning foundation model that aligns natural language with heterogeneous scientific representations. The model is pretrained on a 206B-token corpus spanning scientific text, pure sequences, and sequence-text pairs, then aligned via SFT on 40M instructions, annealed cold-start bootstrapping to elicit long-form chain-of-thought, and reinforcement learning with task-specific reward shaping, which instills deliberate scientific reasoning. It supports four capability families, covering up to 103 tasks across workflows: (i) faithful translation between text and scientific formats, (ii) text/knowledge extraction, (iii) property prediction, (iv) property classification, (v) unconditional and conditional sequence generation and design. Compared with specialist systems, our approach broadens instruction coverage, improves cross-domain generalization, and enhances fidelity. We detail data curation and training and show that cross-discipline learning strengthens transfer and downstream reliability. The model, instruct tuning datasets and the evaluation code are open-sourced at https://huggingface.co/SciReason and https://github.com/open-sciencelab/SciReason.

We present GLM-4.1V-Thinking, a vision-language model (VLM) designed to advance general-purpose multimodal reasoning. In this report, we share our key findings in the development of the reasoning-centric training framework. We first develop a capable vision foundation model with significant potential through large-scale pre-training, which arguably sets the upper bound for the final performance. Reinforcement Learning with Curriculum Sampling (RLCS) then unlocks the full potential of the model, leading to comprehensive capability enhancement across a diverse range of tasks, including STEM problem solving, video understanding, content recognition, coding, grounding, GUI-based agents, and long document understanding, among others. To facilitate research in this field, we open-source GLM-4.1V-9B-Thinking, which achieves state-of-the-art performance among models of comparable size. In a comprehensive evaluation across 28 public benchmarks, our model outperforms Qwen2.5-VL-7B on nearly all tasks and achieves comparable or even superior performance on 18 benchmarks relative to the significantly larger Qwen2.5-VL-72B. Notably, GLM-4.1V-9B-Thinking also demonstrates competitive or superior performance compared to closed-source models such as GPT-4o on challenging tasks including long document understanding and STEM reasoning, further underscoring its strong capabilities. Code, models and more information are released at https://github.com/THUDM/GLM-4.1V-Thinking.

To advance the neural encoding of Portuguese (PT), and a fortiori the technological preparation of this language for the digital age, we developed a Transformer-based foundation model that sets a new state of the art in this respect for two of its variants, namely European Portuguese from Portugal (PT-PT) and American Portuguese from Brazil (PT-BR). To develop this encoder, which we named Albertina PT-*, a strong model was used as a starting point, DeBERTa, and its pre-training was done over data sets of Portuguese, namely over a data set we gathered for PT-PT and over the brWaC corpus for PT-BR. The performance of Albertina and competing models was assessed by evaluating them on prominent downstream language processing tasks adapted for Portuguese. Both Albertina PT-PT and PT-BR versions are distributed free of charge and under the most permissive license possible and can be run on consumer-grade hardware, thus seeking to contribute to the advancement of research and innovation in language technology for Portuguese.

Transformers dominate modern sequence modeling, but their quadratic attention incurs substantial computational cost. Subquadratic architectures offer a scalable alternative. However, it remains unclear which designs yield the most effective sequence models. We compare three leading approaches: xLSTM, Mamba-2, and Gated DeltaNet. We evaluate these models on tasks with complex dependencies: (1) code-model pre-training, (2) distillation of code models from large language models, and (3) pre-training of time-series foundation models. Across these settings, xLSTM delivers the strongest overall performance. To explain xLSTM's advantage, we present a unified formulation and analyze the underlying architectural mechanisms, focusing on state tracking and memory dynamics. Our results show that xLSTM enables more flexible and stable memory correction via its gating scheme. We corroborate these findings on controlled synthetic length-generalization tasks. Overall, our findings indicate that xLSTM's gains on complex tasks stem from robust state tracking and accumulation.

We launch EVA, a vision-centric foundation model to explore the limits of visual representation at scale using only publicly accessible data. EVA is a vanilla ViT pre-trained to reconstruct the masked out image-text aligned vision features conditioned on visible image patches. Via this pretext task, we can efficiently scale up EVA to one billion parameters, and sets new records on a broad range of representative vision downstream tasks, such as image recognition, video action recognition, object detection, instance segmentation and semantic segmentation without heavy supervised training. Moreover, we observe quantitative changes in scaling EVA result in qualitative changes in transfer learning performance that are not present in other models. For instance, EVA takes a great leap in the challenging large vocabulary instance segmentation task: our model achieves almost the same state-of-the-art performance on LVISv1.0 dataset with over a thousand categories and COCO dataset with only eighty categories. Beyond a pure vision encoder, EVA can also serve as a vision-centric, multi-modal pivot to connect images and text. We find initializing the vision tower of a giant CLIP from EVA can greatly stabilize the training and outperform the training from scratch counterpart with much fewer samples and less compute, providing a new direction for scaling up and accelerating the costly training of multi-modal foundation models. To facilitate future research, we release all the code and models at https://github.com/baaivision/EVA.

A modern paradigm for generalization in machine learning and AI consists of pre-training a task-agnostic foundation model, generally obtained using self-supervised and multimodal contrastive learning. The resulting representations can be used for prediction on a downstream task for which no labeled data is available. We present a theoretical framework to better understand this approach, called zero-shot prediction. We identify the target quantities that zero-shot prediction aims to learn, or learns in passing, and the key conditional independence relationships that enable its generalization ability.

The human ability to seamlessly perform multimodal reasoning and physical interaction in the open world is a core goal for general-purpose embodied intelligent systems. Recent vision-language-action (VLA) models, which are co-trained on large-scale robot and visual-text data, have demonstrated notable progress in general robot control. However, they still fail to achieve human-level flexibility in interleaved reasoning and interaction. In this work, introduce EO-Robotics, consists of EO-1 model and EO-Data1.5M dataset. EO-1 is a unified embodied foundation model that achieves superior performance in multimodal embodied reasoning and robot control through interleaved vision-text-action pre-training. The development of EO-1 is based on two key pillars: (i) a unified architecture that processes multimodal inputs indiscriminately (image, text, video, and action), and (ii) a massive, high-quality multimodal embodied reasoning dataset, EO-Data1.5M, which contains over 1.5 million samples with emphasis on interleaved vision-text-action comprehension. EO-1 is trained through synergies between auto-regressive decoding and flow matching denoising on EO-Data1.5M, enabling seamless robot action generation and multimodal embodied reasoning. Extensive experiments demonstrate the effectiveness of interleaved vision-text-action learning for open-world understanding and generalization, validated through a variety of long-horizon, dexterous manipulation tasks across multiple embodiments. This paper details the architecture of EO-1, the data construction strategy of EO-Data1.5M, and the training methodology, offering valuable insights for developing advanced embodied foundation models.

In recent years, large language models (LLMs) have transformed natural language understanding through vast datasets and large-scale parameterization. Inspired by this success, we present SpecCLIP, a foundation model framework that extends LLM-inspired methodologies to stellar spectral analysis. Stellar spectra, akin to structured language, encode rich physical and chemical information about stars. By training foundation models on large-scale spectral datasets, our goal is to learn robust and informative embeddings that support diverse downstream applications. As a proof of concept, SpecCLIP involves pre-training on two spectral types--LAMOST low-resolution and Gaia XP--followed by contrastive alignment using the CLIP (Contrastive Language-Image Pre-training) framework, adapted to associate spectra from different instruments. This alignment is complemented by auxiliary decoders that preserve spectrum-specific information and enable translation (prediction) between spectral types, with the former achieved by maximizing mutual information between embeddings and input spectra. The result is a cross-spectrum framework enabling intrinsic calibration and flexible applications across instruments. We demonstrate that fine-tuning these models on moderate-sized labeled datasets improves adaptability to tasks such as stellar-parameter estimation and chemical-abundance determination. SpecCLIP also enhances the accuracy and precision of parameter estimates benchmarked against external survey data. Additionally, its similarity search and cross-spectrum prediction capabilities offer potential for anomaly detection. Our results suggest that contrastively trained foundation models enriched with spectrum-aware decoders can advance precision stellar spectroscopy.

Large language models (LLMs) have showcased profound capabilities in language understanding and generation, facilitating a wide array of applications. However, there is a notable paucity of detailed, open-sourced methodologies on efficiently scaling LLMs beyond 50 billion parameters with minimum trial-and-error cost and computational resources. In this report, we introduce Tele-FLM (aka FLM-2), a 52B open-sourced multilingual large language model that features a stable, efficient pre-training paradigm and enhanced factual judgment capabilities. Tele-FLM demonstrates superior multilingual language modeling abilities, measured by BPB on textual corpus. Besides, in both English and Chinese foundation model evaluation, it is comparable to strong open-sourced models that involve larger pre-training FLOPs, such as Llama2-70B and DeepSeek-67B. In addition to the model weights, we share the core designs, engineering practices, and training details, which we expect to benefit both the academic and industrial communities.