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Jul 13

Examining the Source of Defects from a Mechanical Perspective for 3D Anomaly Detection

In this paper, we explore a novel approach to 3D anomaly detection (AD) that goes beyond merely identifying anomalies based on structural characteristics. Our primary perspective is that most anomalies arise from unpredictable defective forces originating from both internal and external sources. To address these anomalies, we seek out opposing forces that can help correct them. Therefore, we introduce the Mechanics Complementary Model-based Framework for the 3D-AD task (MC4AD), which generates internal and external corrective forces for each point. We first propose a Diverse Anomaly-Generation (DA-Gen) module designed to simulate various types of anomalies. Next, we present the Corrective Force Prediction Network (CFP-Net), which uses complementary representations for point-level analysis to simulate the different contributions from internal and external corrective forces. To ensure the corrective forces are constrained effectively, we have developed a combined loss function that includes a new symmetric loss and an overall loss. Notably, we implement a Hierarchical Quality Control (HQC) strategy based on a three-way decision process and contribute a dataset titled Anomaly-IntraVariance, which incorporates intraclass variance to evaluate our model. As a result, the proposed MC4AD has been proven effective through theory and experimentation. The experimental results demonstrate that our approach yields nine state-of-the-art performances, achieving optimal results with minimal parameters and the fastest inference speed across five existing datasets, in addition to the proposed Anomaly-IntraVariance dataset. The source is available at https://github.com/hzzzzzhappy/MC4AD

  • 6 authors
·
May 9, 2025

Fuxi-DA: A Generalized Deep Learning Data Assimilation Framework for Assimilating Satellite Observations

Data assimilation (DA), as an indispensable component within contemporary Numerical Weather Prediction (NWP) systems, plays a crucial role in generating the analysis that significantly impacts forecast performance. Nevertheless, the development of an efficient DA system poses significant challenges, particularly in establishing intricate relationships between the background data and the vast amount of multi-source observation data within limited time windows in operational settings. To address these challenges, researchers design complex pre-processing methods for each observation type, leveraging approximate modeling and the power of super-computing clusters to expedite solutions. The emergence of deep learning (DL) models has been a game-changer, offering unified multi-modal modeling, enhanced nonlinear representation capabilities, and superior parallelization. These advantages have spurred efforts to integrate DL models into various domains of weather modeling. Remarkably, DL models have shown promise in matching, even surpassing, the forecast accuracy of leading operational NWP models worldwide. This success motivates the exploration of DL-based DA frameworks tailored for weather forecasting models. In this study, we introduces FuxiDA, a generalized DL-based DA framework for assimilating satellite observations. By assimilating data from Advanced Geosynchronous Radiation Imager (AGRI) aboard Fengyun-4B, FuXi-DA consistently mitigates analysis errors and significantly improves forecast performance. Furthermore, through a series of single-observation experiments, Fuxi-DA has been validated against established atmospheric physics, demonstrating its consistency and reliability.

  • 6 authors
·
Apr 12, 2024

Towards Distribution-Agnostic Generalized Category Discovery

Data imbalance and open-ended distribution are two intrinsic characteristics of the real visual world. Though encouraging progress has been made in tackling each challenge separately, few works dedicated to combining them towards real-world scenarios. While several previous works have focused on classifying close-set samples and detecting open-set samples during testing, it's still essential to be able to classify unknown subjects as human beings. In this paper, we formally define a more realistic task as distribution-agnostic generalized category discovery (DA-GCD): generating fine-grained predictions for both close- and open-set classes in a long-tailed open-world setting. To tackle the challenging problem, we propose a Self-Balanced Co-Advice contrastive framework (BaCon), which consists of a contrastive-learning branch and a pseudo-labeling branch, working collaboratively to provide interactive supervision to resolve the DA-GCD task. In particular, the contrastive-learning branch provides reliable distribution estimation to regularize the predictions of the pseudo-labeling branch, which in turn guides contrastive learning through self-balanced knowledge transfer and a proposed novel contrastive loss. We compare BaCon with state-of-the-art methods from two closely related fields: imbalanced semi-supervised learning and generalized category discovery. The effectiveness of BaCon is demonstrated with superior performance over all baselines and comprehensive analysis across various datasets. Our code is publicly available.

  • 10 authors
·
Oct 2, 2023

A Survey on Knowledge Distillation of Large Language Models

This survey presents an in-depth exploration of knowledge distillation (KD) techniques within the realm of Large Language Models (LLMs), spotlighting the pivotal role of KD in transferring sophisticated capabilities from proprietary giants such as GPT-4 to accessible, open-source models like LLaMA and Mistral. Amidst the evolving AI landscape, this work elucidates the critical disparities between proprietary and open-source LLMs, demonstrating how KD serves as an essential conduit for imbuing the latter with the former's advanced functionalities and nuanced understandings. Our survey is meticulously structured around three foundational pillars: algorithm, skill, and verticalization -- providing a comprehensive examination of KD mechanisms, the enhancement of specific cognitive abilities, and their practical implications across diverse fields. Crucially, the survey navigates the intricate interplay between data augmentation (DA) and KD, illustrating how DA emerges as a powerful paradigm within the KD framework to bolster LLMs' performance. By leveraging DA to generate context-rich, skill-specific training data, KD transcends traditional boundaries, enabling open-source models to approximate the contextual adeptness, ethical alignment, and deep semantic insights characteristic of their proprietary counterparts. This work aims to provide an insightful guide for researchers and practitioners, offering a detailed overview of current methodologies in knowledge distillation and proposing future research directions. By bridging the gap between proprietary and open-source LLMs, this survey underscores the potential for more accessible, efficient, and sustainable AI solutions, fostering a more inclusive and equitable landscape in AI advancements. An associated Github repository is available at https://github.com/Tebmer/Awesome-Knowledge-Distillation-of-LLMs.

  • 9 authors
·
Feb 20, 2024

GST-VLA: Structured Gaussian Spatial Tokens for 3D Depth-Aware Vision-Language-Action Models

VLA models encode visual observations as 2D patch tokens with no intrinsic geometric structure. We introduce GST-VLA with two contributions. First, the Gaussian Spatial Tokenizer (GST) converts frozen dense depth and frozen semantic patch features into N_g{=}128 anisotropic 3D Gaussian primitives, each parameterized by a metric residual mean μin R^3, log-scale covariance log σin R^3, and learned opacity αin (0,1). The covariance eigenstructure encodes local surface orientation, and opacity provides per-primitive geometric confidence, both inaccessible from scalar depth. Spatial attention pooling with learned queries concentrates the fixed token budget on geometrically salient regions rather than distributing uniformly. Second, 3D Depth-Aware Chain-of-Thought (DA-CoT) reasoning supervises four structured intermediate spatial thoughts, covering 3D object grounding, grasp affordance contact geometry, pairwise metric distances, and coarse SE(3) waypoints, as explicit generation targets in the training loss. A cross-attention sublayer at every VLM transformer block provides direct access to the raw 256-primitive Gaussian field during DA-CoT generation. A 300M-parameter flow-matching action expert with mixture-of-experts feedforward sublayers decodes 7-DoF delta action chunks via conditional ODE integration, conditioned on both VLM hidden states and DA-CoT outputs through dual cross-attention. Trained with composite L_flow + L_CoT + L_depth across three progressive stages, GST-VLA achieves 96.4% on LIBERO (+2.0%), and 80.2% on SimplerEnv (+5.4%). Ablations isolate the contribution of each GST component, each DA-CoT thought, and each training stage, confirming independent and synergistic gains concentrated on precision demanding tasks.

  • 3 authors
·
Mar 9

FairDomain: Achieving Fairness in Cross-Domain Medical Image Segmentation and Classification

Addressing fairness in artificial intelligence (AI), particularly in medical AI, is crucial for ensuring equitable healthcare outcomes. Recent efforts to enhance fairness have introduced new methodologies and datasets in medical AI. However, the fairness issue under the setting of domain transfer is almost unexplored, while it is common that clinics rely on different imaging technologies (e.g., different retinal imaging modalities) for patient diagnosis. This paper presents FairDomain, a pioneering systemic study into algorithmic fairness under domain shifts, employing state-of-the-art domain adaptation (DA) and generalization (DG) algorithms for both medical segmentation and classification tasks to understand how biases are transferred between different domains. We also introduce a novel plug-and-play fair identity attention (FIA) module that adapts to various DA and DG algorithms to improve fairness by using self-attention to adjust feature importance based on demographic attributes. Additionally, we curate the first fairness-focused dataset with two paired imaging modalities for the same patient cohort on medical segmentation and classification tasks, to rigorously assess fairness in domain-shift scenarios. Excluding the confounding impact of demographic distribution variation between source and target domains will allow clearer quantification of the performance of domain transfer models. Our extensive evaluations reveal that the proposed FIA significantly enhances both model performance accounted for fairness across all domain shift settings (i.e., DA and DG) with respect to different demographics, which outperforms existing methods on both segmentation and classification. The code and data can be accessed at https://ophai.hms.harvard.edu/datasets/harvard-fairdomain20k.

  • 9 authors
·
Jul 11, 2024

Guided Data Augmentation for Offline Reinforcement Learning and Imitation Learning

In offline reinforcement learning (RL), an RL agent learns to solve a task using only a fixed dataset of previously collected data. While offline RL has been successful in learning real-world robot control policies, it typically requires large amounts of expert-quality data to learn effective policies that generalize to out-of-distribution states. Unfortunately, such data is often difficult and expensive to acquire in real-world tasks. Several recent works have leveraged data augmentation (DA) to inexpensively generate additional data, but most DA works apply augmentations in a random fashion and ultimately produce highly suboptimal augmented experience. In this work, we propose Guided Data Augmentation (GuDA), a human-guided DA framework that generates expert-quality augmented data. The key insight behind GuDA is that while it may be difficult to demonstrate the sequence of actions required to produce expert data, a user can often easily characterize when an augmented trajectory segment represents progress toward task completion. Thus, a user can restrict the space of possible augmentations to automatically reject suboptimal augmented data. To extract a policy from GuDA, we use off-the-shelf offline reinforcement learning and behavior cloning algorithms. We evaluate GuDA on a physical robot soccer task as well as simulated D4RL navigation tasks, a simulated autonomous driving task, and a simulated soccer task. Empirically, GuDA enables learning given a small initial dataset of potentially suboptimal experience and outperforms a random DA strategy as well as a model-based DA strategy.

  • 5 authors
·
Oct 27, 2023

Revisiting Class-Incremental Learning with Pre-Trained Models: Generalizability and Adaptivity are All You Need

Class-incremental learning (CIL) aims to adapt to emerging new classes without forgetting old ones. Traditional CIL models are trained from scratch to continually acquire knowledge as data evolves. Recently, pre-training has achieved substantial progress, making vast pre-trained models (PTMs) accessible for CIL. Contrary to traditional methods, PTMs possess generalizable embeddings, which can be easily transferred. In this work, we revisit CIL with PTMs and argue that the core factors in CIL are adaptivity for model updating and generalizability for knowledge transferring. 1) We first reveal that frozen PTM can already provide generalizable embeddings for CIL. Surprisingly, a simple baseline (SimpleCIL) which continually sets the classifiers of PTM to prototype features can beat state-of-the-art even without training on the downstream task. 2) Due to the distribution gap between pre-trained and downstream datasets, PTM can be further cultivated with adaptivity via model adapting. We propose ADapt And Merge (ADAM), which aggregates the embeddings of PTM and adapted models for classifier construction. ADAM is a general framework that can be orthogonally combined with any parameter-efficient tuning method, which holds the advantages of PTM's generalizability and adapted model's adaptivity. 3) Additionally, we find previous benchmarks are unsuitable in the era of PTM due to data overlapping and propose four new benchmarks for assessment, namely ImageNet-A, ObjectNet, OmniBenchmark, and VTAB. Extensive experiments validate the effectiveness of ADAM with a unified and concise framework.

  • 4 authors
·
Mar 13, 2023

Vision-Language Generative Model for View-Specific Chest X-ray Generation

Synthetic medical data generation has opened up new possibilities in the healthcare domain, offering a powerful tool for simulating clinical scenarios, enhancing diagnostic and treatment quality, gaining granular medical knowledge, and accelerating the development of unbiased algorithms. In this context, we present a novel approach called ViewXGen, designed to overcome the limitations of existing methods that rely on general domain pipelines using only radiology reports to generate frontal-view chest X-rays. Our approach takes into consideration the diverse view positions found in the dataset, enabling the generation of chest X-rays with specific views, which marks a significant advancement in the field. To achieve this, we introduce a set of specially designed tokens for each view position, tailoring the generation process to the user's preferences. Furthermore, we leverage multi-view chest X-rays as input, incorporating valuable information from different views within the same study. This integration rectifies potential errors and contributes to faithfully capturing abnormal findings in chest X-ray generation. To validate the effectiveness of our approach, we conducted statistical analyses, evaluating its performance in a clinical efficacy metric on the MIMIC-CXR dataset. Also, human evaluation demonstrates the remarkable capabilities of ViewXGen, particularly in producing realistic view-specific X-rays that closely resemble the original images.

  • 8 authors
·
Feb 23, 2023

Genie Sim 3.0 : A High-Fidelity Comprehensive Simulation Platform for Humanoid Robot

The development of robust and generalizable robot learning models is critically contingent upon the availability of large-scale, diverse training data and reliable evaluation benchmarks. Collecting data in the physical world poses prohibitive costs and scalability challenges, and prevailing simulation benchmarks frequently suffer from fragmentation, narrow scope, or insufficient fidelity to enable effective sim-to-real transfer. To address these challenges, we introduce Genie Sim 3.0, a unified simulation platform for robotic manipulation. We present Genie Sim Generator, a large language model (LLM)-powered tool that constructs high-fidelity scenes from natural language instructions. Its principal strength resides in rapid and multi-dimensional generalization, facilitating the synthesis of diverse environments to support scalable data collection and robust policy evaluation. We introduce the first benchmark that pioneers the application of LLM for automated evaluation. It leverages LLM to mass-generate evaluation scenarios and employs Vision-Language Model (VLM) to establish an automated assessment pipeline. We also release an open-source dataset comprising more than 10,000 hours of synthetic data across over 200 tasks. Through systematic experimentation, we validate the robust zero-shot sim-to-real transfer capability of our open-source dataset, demonstrating that synthetic data can server as an effective substitute for real-world data under controlled conditions for scalable policy training. For code and dataset details, please refer to: https://github.com/AgibotTech/genie_sim.

  • 19 authors
·
Jan 5

ReCatcher: Towards LLMs Regression Testing for Code Generation

Large Language Models (LLMs) for code generation evolve rapidly through fine-tuning, merging, or new model releases. However, such updates can introduce regressions, not only in correctness but also in code quality and performance. To address this, we present ReCatcher, a regression testing framework for Python code generation. ReCatcher systematically compares two LLMs, typically a current model and a candidate update, across three dimensions: logical correctness, static code quality, and execution performance. We apply ReCatcher to assess regressions across three update scenarios, fine-tuning, merging, and model release, using CodeLlama, DeepSeek-Coder, and GPT-4o. Our evaluation shows that fine-tuning with cross-language datasets increases syntax errors by up to 12%. Merging with general-purpose models like Llama2 leads to regressions in correctness by up to 18%. GPT-4o introduces regressions of up to 50% in handling missing imports compared to GPT-3.5-turbo, while GPT-4o-mini suffers up to 80% performance degradation in execution time versus GPT-4o. Overall, logical correctness, performance, and error handling (e.g., syntax errors and missing imports) are the most regression-prone areas. Comparing ReCatcher with baseline solutions, it presents better and consistent accuracy across logical and performance aspects. ReCatcher highlights the importance of systematic regression evaluation before adopting new models, while assisting researchers and practitioners in making more informed update decisions.

  • 4 authors
·
Jul 25, 2025

Towards Self-Improving Systematic Cognition for Next-Generation Foundation MLLMs

Despite their impressive capabilities, Multimodal Large Language Models (MLLMs) face challenges with fine-grained perception and complex reasoning. Prevalent multimodal pre-training approaches focus on enhancing perception by training on high-quality image captions due to the extremely high cost of collecting chain-of-thought (CoT) reasoning data for improving reasoning. While leveraging advanced MLLMs for caption generation enhances scalability, the outputs often lack comprehensiveness and accuracy. In this paper, we introduce Self-Improving cognition (SIcog), a self-learning framework designed to construct next-generation foundation MLLMs by enhancing their systematic cognitive capabilities through multimodal pre-training with self-generated data. Specifically, we propose Chain-of-Description, an approach that improves an MLLM's systematic perception by enabling step-by-step visual understanding, ensuring greater comprehensiveness and accuracy. Additionally, we adopt a structured CoT reasoning technique to enable MLLMs to integrate in-depth multimodal reasoning. To construct a next-generation foundation MLLM with self-improved cognition, SIcog first equips an MLLM with systematic perception and reasoning abilities using minimal external annotations. The enhanced models then generate detailed captions and CoT reasoning data, which are further curated through self-consistency. This curated data is ultimately used for multimodal pre-training to develop next-generation foundation models. Extensive experiments on both low- and high-resolution MLLMs across diverse benchmarks demonstrate that, with merely 213K self-generated pre-training samples, SIcog produces next-generation foundation MLLMs with significantly improved cognition, achieving benchmark-leading performance compared to prevalent pre-training approaches.

  • 9 authors
·
Mar 15, 2025 3

ResTok: Learning Hierarchical Residuals in 1D Visual Tokenizers for Autoregressive Image Generation

Existing 1D visual tokenizers for autoregressive (AR) generation largely follow the design principles of language modeling, as they are built directly upon transformers whose priors originate in language, yielding single-hierarchy latent tokens and treating visual data as flat sequential token streams. However, this language-like formulation overlooks key properties of vision, particularly the hierarchical and residual network designs that have long been essential for convergence and efficiency in visual models. To bring "vision" back to vision, we propose the Residual Tokenizer (ResTok), a 1D visual tokenizer that builds hierarchical residuals for both image tokens and latent tokens. The hierarchical representations obtained through progressively merging enable cross-level feature fusion at each layer, substantially enhancing representational capacity. Meanwhile, the semantic residuals between hierarchies prevent information overlap, yielding more concentrated latent distributions that are easier for AR modeling. Cross-level bindings consequently emerge without any explicit constraints. To accelerate the generation process, we further introduce a hierarchical AR generator that substantially reduces sampling steps by predicting an entire level of latent tokens at once rather than generating them strictly token-by-token. Extensive experiments demonstrate that restoring hierarchical residual priors in visual tokenization significantly improves AR image generation, achieving a gFID of 2.34 on ImageNet-256 with only 9 sampling steps. Code is available at https://github.com/Kwai-Kolors/ResTok.

  • 6 authors
·
Jan 7 2

Image generation with shortest path diffusion

The field of image generation has made significant progress thanks to the introduction of Diffusion Models, which learn to progressively reverse a given image corruption. Recently, a few studies introduced alternative ways of corrupting images in Diffusion Models, with an emphasis on blurring. However, these studies are purely empirical and it remains unclear what is the optimal procedure for corrupting an image. In this work, we hypothesize that the optimal procedure minimizes the length of the path taken when corrupting an image towards a given final state. We propose the Fisher metric for the path length, measured in the space of probability distributions. We compute the shortest path according to this metric, and we show that it corresponds to a combination of image sharpening, rather than blurring, and noise deblurring. While the corruption was chosen arbitrarily in previous work, our Shortest Path Diffusion (SPD) determines uniquely the entire spatiotemporal structure of the corruption. We show that SPD improves on strong baselines without any hyperparameter tuning, and outperforms all previous Diffusion Models based on image blurring. Furthermore, any small deviation from the shortest path leads to worse performance, suggesting that SPD provides the optimal procedure to corrupt images. Our work sheds new light on observations made in recent works and provides a new approach to improve diffusion models on images and other types of data.

  • 8 authors
·
Jun 1, 2023

Cheers: Decoupling Patch Details from Semantic Representations Enables Unified Multimodal Comprehension and Generation

A recent cutting-edge topic in multimodal modeling is to unify visual comprehension and generation within a single model. However, the two tasks demand mismatched decoding regimes and visual representations, making it non-trivial to jointly optimize within a shared feature space. In this work, we present Cheers, a unified multimodal model that decouples patch-level details from semantic representations, thereby stabilizing semantics for multimodal understanding and improving fidelity for image generation via gated detail residuals. Cheers includes three key components: (i) a unified vision tokenizer that encodes and compresses image latent states into semantic tokens for efficient LLM conditioning, (ii) an LLM-based Transformer that unifies autoregressive decoding for text generation and diffusion decoding for image generation, and (iii) a cascaded flow matching head that decodes visual semantics first and then injects semantically gated detail residuals from the vision tokenizer to refine high-frequency content. Experiments on popular benchmarks demonstrate that Cheers matches or surpasses advanced UMMs in both visual understanding and generation. Cheers also achieves 4x token compression, enabling more efficient high-resolution image encoding and generation. Notably, Cheers outperforms the Tar-1.5B on the popular benchmarks GenEval and MMBench, while requiring only 20% of the training cost, indicating effective and efficient (i.e., 4x token compression) unified multimodal modeling. We will release all code and data for future research.

  • 22 authors
·
Mar 13 3

Let's Fuse Step by Step: A Generative Fusion Decoding Algorithm with LLMs for Multi-modal Text Recognition

We introduce "Generative Fusion Decoding" (GFD), a novel shallow fusion framework, utilized to integrate Large Language Models (LLMs) into multi-modal text recognition systems such as automatic speech recognition (ASR) and optical character recognition (OCR). We derive the formulas necessary to enable GFD to operate across mismatched token spaces of different models by mapping text token space to byte token space, enabling seamless fusion during the decoding process. The framework is plug-and-play, compatible with various auto-regressive models, and does not require re-training for feature alignment, thus overcoming limitations of previous fusion techniques. We highlight three main advantages of GFD: First, by simplifying the complexity of aligning different model sample spaces, GFD allows LLMs to correct errors in tandem with the recognition model, reducing computation latencies. Second, the in-context learning ability of LLMs is fully capitalized by GFD, increasing robustness in long-form speech recognition and instruction aware speech recognition. Third, GFD enables fusing recognition models deficient in Chinese text recognition with LLMs extensively trained on Chinese. Our evaluation demonstrates that GFD significantly improves performance in ASR and OCR tasks, with ASR reaching state-of-the-art in the NTUML2021 benchmark. GFD provides a significant step forward in model integration, offering a unified solution that could be widely applicable to leveraging existing pre-trained models through step by step fusion.

  • 7 authors
·
May 23, 2024 2

Generative AI for Medical Imaging: extending the MONAI Framework

Recent advances in generative AI have brought incredible breakthroughs in several areas, including medical imaging. These generative models have tremendous potential not only to help safely share medical data via synthetic datasets but also to perform an array of diverse applications, such as anomaly detection, image-to-image translation, denoising, and MRI reconstruction. However, due to the complexity of these models, their implementation and reproducibility can be difficult. This complexity can hinder progress, act as a use barrier, and dissuade the comparison of new methods with existing works. In this study, we present MONAI Generative Models, a freely available open-source platform that allows researchers and developers to easily train, evaluate, and deploy generative models and related applications. Our platform reproduces state-of-art studies in a standardised way involving different architectures (such as diffusion models, autoregressive transformers, and GANs), and provides pre-trained models for the community. We have implemented these models in a generalisable fashion, illustrating that their results can be extended to 2D or 3D scenarios, including medical images with different modalities (like CT, MRI, and X-Ray data) and from different anatomical areas. Finally, we adopt a modular and extensible approach, ensuring long-term maintainability and the extension of current applications for future features.

  • 24 authors
·
Jul 27, 2023

DreamSync: Aligning Text-to-Image Generation with Image Understanding Feedback

Despite their wide-spread success, Text-to-Image models (T2I) still struggle to produce images that are both aesthetically pleasing and faithful to the user's input text. We introduce DreamSync, a model-agnostic training algorithm by design that improves T2I models to be faithful to the text input. DreamSync builds off a recent insight from TIFA's evaluation framework -- that large vision-language models (VLMs) can effectively identify the fine-grained discrepancies between generated images and the text inputs. DreamSync uses this insight to train T2I models without any labeled data; it improves T2I models using its own generations. First, it prompts the model to generate several candidate images for a given input text. Then, it uses two VLMs to select the best generation: a Visual Question Answering model that measures the alignment of generated images to the text, and another that measures the generation's aesthetic quality. After selection, we use LoRA to iteratively finetune the T2I model to guide its generation towards the selected best generations. DreamSync does not need any additional human annotation. model architecture changes, or reinforcement learning. Despite its simplicity, DreamSync improves both the semantic alignment and aesthetic appeal of two diffusion-based T2I models, evidenced by multiple benchmarks (+1.7% on TIFA, +2.9% on DSG1K, +3.4% on VILA aesthetic) and human evaluation.

google Google
·
Nov 28, 2023

PIGEON: Optimizing CUDA Code Generator for End-to-End Training and Inference of Relational Graph Neural Networks

Relational graph neural networks (RGNNs) are graph neural networks (GNNs) with dedicated structures for modeling the different types of nodes and/or edges in heterogeneous graphs. While RGNNs have been increasingly adopted in many real-world applications due to their versatility and accuracy, they pose performance and system design challenges due to their inherent computation patterns, gap between the programming interface and kernel APIs, and heavy programming efforts in optimizing kernels caused by their coupling with data layout and heterogeneity. To systematically address these challenges, we propose Pigeon, a novel two-level intermediate representation (IR) and its code generator framework, that (a) represents the key properties of the RGNN models to bridge the gap between the programming interface and kernel APIs, (b) decouples model semantics, data layout, and operators-specific optimization from each other to reduce programming efforts, (c) expresses and leverages optimization opportunities in inter-operator transforms, data layout, and operator-specific schedules. By building on one general matrix multiply (GEMM) template and a node/edge traversal template, Pigeon achieves up to 7.8x speed-up in inference and 5.6x speed-up in training compared with the state-of-the-art public systems in select models, i.e., RGCN, RGAT, HGT, when running heterogeneous graphs provided by Deep Graph Library (DGL) and Open Graph Benchmark (OGB). Pigeon also triggers fewer out-of-memory (OOM) errors. In addition, we propose linear operator fusion and compact materialization to further accelerate the system by up to 2.2x.

  • 7 authors
·
Jan 16, 2023

IntroSVG: Learning from Rendering Feedback for Text-to-SVG Generation via an Introspective Generator-Critic Framework

Scalable Vector Graphics (SVG) are central to digital design due to their inherent scalability and editability. Despite significant advancements in content generation enabled by Visual Language Models (VLMs), existing text-to-SVG generation methods are limited by a core challenge: the autoregressive training process does not incorporate visual perception of the final rendered image, which fundamentally constrains generation quality. To address this limitation, we propose an Introspective SVG Generation Framework (IntroSVG). At its core, the framework instantiates a unified VLM that operates in a closed loop, assuming dual roles of both generator and critic. Specifically, through Supervised Fine-Tuning (SFT), the model learns to draft SVGs and to provide feedback on their rendered outputs; moreover, we systematically convert early-stage failures into high-quality error-correction training data, thereby enhancing model robustness. Subsequently, we leverage a high-capacity teacher VLM to construct a preference dataset and further align the generator's policy through Direct Preference Optimization (DPO). During inference, the optimized generator and critic operate collaboratively in an iterative "generate-review-refine" cycle, starting from imperfect intermediate drafts to autonomously improve output quality. Experimental results demonstrate that our method achieves state-of-the-art performance across several key evaluation metrics, generating SVGs with more complex structures, stronger semantic alignment, and greater editability. These results corroborate the effectiveness of incorporating explicit visual feedback into the generation loop.

  • 7 authors
·
Mar 9

FronTalk: Benchmarking Front-End Development as Conversational Code Generation with Multi-Modal Feedback

We present FronTalk, a benchmark for front-end code generation that pioneers the study of a unique interaction dynamic: conversational code generation with multi-modal feedback. In front-end development, visual artifacts such as sketches, mockups and annotated creenshots are essential for conveying design intent, yet their role in multi-turn code generation remains largely unexplored. To address this gap, we focus on the front-end development task and curate FronTalk, a collection of 100 multi-turn dialogues derived from real-world websites across diverse domains such as news, finance, and art. Each turn features both a textual instruction and an equivalent visual instruction, each representing the same user intent. To comprehensively evaluate model performance, we propose a novel agent-based evaluation framework leveraging a web agent to simulate users and explore the website, and thus measuring both functional correctness and user experience. Evaluation of 20 models reveals two key challenges that are under-explored systematically in the literature: (1) a significant forgetting issue where models overwrite previously implemented features, resulting in task failures, and (2) a persistent challenge in interpreting visual feedback, especially for open-source vision-language models (VLMs). We propose a strong baseline to tackle the forgetting issue with AceCoder, a method that critiques the implementation of every past instruction using an autonomous web agent. This approach significantly reduces forgetting to nearly zero and improves the performance by up to 9.3% (56.0% to 65.3%). Overall, we aim to provide a solid foundation for future research in front-end development and the general interaction dynamics of multi-turn, multi-modal code generation. Code and data are released at https://github.com/shirley-wu/frontalk

  • 7 authors
·
Dec 5, 2025

PROMPTMINER: Black-Box Prompt Stealing against Text-to-Image Generative Models via Reinforcement Learning and Fuzz Optimization

Text-to-image (T2I) generative models such as Stable Diffusion and FLUX can synthesize realistic, high-quality images directly from textual prompts. The resulting image quality depends critically on well-crafted prompts that specify both subjects and stylistic modifiers, which have become valuable digital assets. However, the rising value and ubiquity of high-quality prompts expose them to security and intellectual-property risks. One key threat is the prompt stealing attack, i.e., the task of recovering the textual prompt that generated a given image. Prompt stealing enables unauthorized extraction and reuse of carefully engineered prompts, yet it can also support beneficial applications such as data attribution, model provenance analysis, and watermarking validation. Existing approaches often assume white-box gradient access, require large-scale labeled datasets for supervised training, or rely solely on captioning without explicit optimization, limiting their practicality and adaptability. To address these challenges, we propose PROMPTMINER, a black-box prompt stealing framework that decouples the task into two phases: (1) a reinforcement learning-based optimization phase to reconstruct the primary subject, and (2) a fuzzing-driven search phase to recover stylistic modifiers. Experiments across multiple datasets and diffusion backbones demonstrate that PROMPTMINER achieves superior results, with CLIP similarity up to 0.958 and textual alignment with SBERT up to 0.751, surpassing all baselines. Even when applied to in-the-wild images with unknown generators, it outperforms the strongest baseline by 7.5 percent in CLIP similarity, demonstrating better generalization. Finally, PROMPTMINER maintains strong performance under defensive perturbations, highlighting remarkable robustness. Code: https://github.com/aaFrostnova/PromptMiner

  • 7 authors
·
Nov 26, 2025

Evaluating LLMs on Sequential API Call Through Automated Test Generation

By integrating tools from external APIs, Large Language Models (LLMs) have expanded their promising capabilities in a diverse spectrum of complex real-world tasks. However, testing, evaluation, and analysis of LLM tool use remain in their early stages. Most existing benchmarks rely on manually collected test cases, many of which cannot be automatically checked for semantic correctness and instead depend on static methods such as string matching. Additionally, these benchmarks often overlook the complex interactions that occur between sequential API calls, which are common in real-world applications. To fill the gap, in this paper, we introduce StateGen, an automated framework designed to generate diverse coding tasks involving sequential API interactions. StateGen combines state-machine-based API constraint solving and validation, energy-based sampling, and control-flow injection to generate executable programs. These programs are then translated into human-like natural language task descriptions through a collaboration of two LLM agents. Utilizing StateGen, we construct StateEval, a benchmark encompassing 120 verified test cases spanning across three representative scenarios: Session Service, Tensor Operation, and ElevenLabs MCP. Experimental results confirm that StateGen can effectively generate challenging and realistic API-oriented tasks, highlighting areas for improvement in current LLMs incorporating APIs.We make our framework and benchmark publicly available to support future research.

  • 7 authors
·
Jul 12, 2025 1

Towards Holistic Visual Quality Assessment of AI-Generated Videos: A LLM-Based Multi-Dimensional Evaluation Model

The development of AI-Generated Video (AIGV) technology has been remarkable in recent years, significantly transforming the paradigm of video content production. However, AIGVs still suffer from noticeable visual quality defects, such as noise, blurriness, frame jitter and low dynamic degree, which severely impact the user's viewing experience. Therefore, an effective automatic visual quality assessment is of great importance for AIGV content regulation and generative model improvement. In this work, we decompose the visual quality of AIGVs into three dimensions: technical quality, motion quality, and video semantics. For each dimension, we design corresponding encoder to achieve effective feature representation. Moreover, considering the outstanding performance of large language models (LLMs) in various vision and language tasks, we introduce a LLM as the quality regression module. To better enable the LLM to establish reasoning associations between multi-dimensional features and visual quality, we propose a specially designed multi-modal prompt engineering framework. Additionally, we incorporate LoRA fine-tuning technology during the training phase, allowing the LLM to better adapt to specific tasks. Our proposed method achieved second place in the NTIRE 2025 Quality Assessment of AI-Generated Content Challenge: Track 2 AI Generated video, demonstrating its effectiveness. Codes can be obtained at https://github.com/QiZelu/AIGVEval.

  • 7 authors
·
Jun 5, 2025

Towards a Unified Multi-Dimensional Evaluator for Text Generation

Multi-dimensional evaluation is the dominant paradigm for human evaluation in Natural Language Generation (NLG), i.e., evaluating the generated text from multiple explainable dimensions, such as coherence and fluency. However, automatic evaluation in NLG is still dominated by similarity-based metrics, and we lack a reliable framework for a more comprehensive evaluation of advanced models. In this paper, we propose a unified multi-dimensional evaluator UniEval for NLG. We re-frame NLG evaluation as a Boolean Question Answering (QA) task, and by guiding the model with different questions, we can use one evaluator to evaluate from multiple dimensions. Furthermore, thanks to the unified Boolean QA format, we are able to introduce an intermediate learning phase that enables UniEval to incorporate external knowledge from multiple related tasks and gain further improvement. Experiments on three typical NLG tasks show that UniEval correlates substantially better with human judgments than existing metrics. Specifically, compared to the top-performing unified evaluators, UniEval achieves a 23% higher correlation on text summarization, and over 43% on dialogue response generation. Also, UniEval demonstrates a strong zero-shot learning ability for unseen evaluation dimensions and tasks. Source code, data and all pre-trained evaluators are available on our GitHub repository (https://github.com/maszhongming/UniEval).

  • 9 authors
·
Oct 13, 2022

Motion-I2V: Consistent and Controllable Image-to-Video Generation with Explicit Motion Modeling

We introduce Motion-I2V, a novel framework for consistent and controllable image-to-video generation (I2V). In contrast to previous methods that directly learn the complicated image-to-video mapping, Motion-I2V factorizes I2V into two stages with explicit motion modeling. For the first stage, we propose a diffusion-based motion field predictor, which focuses on deducing the trajectories of the reference image's pixels. For the second stage, we propose motion-augmented temporal attention to enhance the limited 1-D temporal attention in video latent diffusion models. This module can effectively propagate reference image's feature to synthesized frames with the guidance of predicted trajectories from the first stage. Compared with existing methods, Motion-I2V can generate more consistent videos even at the presence of large motion and viewpoint variation. By training a sparse trajectory ControlNet for the first stage, Motion-I2V can support users to precisely control motion trajectories and motion regions with sparse trajectory and region annotations. This offers more controllability of the I2V process than solely relying on textual instructions. Additionally, Motion-I2V's second stage naturally supports zero-shot video-to-video translation. Both qualitative and quantitative comparisons demonstrate the advantages of Motion-I2V over prior approaches in consistent and controllable image-to-video generation.

  • 12 authors
·
Jan 29, 2024 8

HoliTok:A Coutinuous Holistic Tokenization with Robust Dual Capabilities of Speech Generation and Understanding

Unified speech foundation models require a holistic tokenization space that is both learnable by language models and decodable into high-quality waveforms. Existing speech tokenizers, however, often fail to satisfy these requirements simultaneously, leading to increased architectural complexity and more involved training designs. We propose HoliTok, a continuous Holistic speech Tokenization model designed for unified generation-understanding modeling. HoliTok encodes 48~kHz speech into a compact 25~Hz sequence of 128-dimensional latents. It is trained with a progressive strategy that jointly preserves signal-level fidelity, incorporates semantic information, and maintains strong latent learnability. Based on this tokenization, we build a unified AR+DiT model for speech synthesis and recognition, where the same latent sequence supports both generation-specific and unified generation-understanding tasks. Experiments show that HoliTok achieves competitive reconstruction fidelity, improves generative learnability for high-quality and controllable synthesis, and, among the evaluated representations, is the only one that operates robustly in our unified generation-understanding architecture without additional optimization tricks. These results suggest that HoliTok serves as an effective speech tokenizer and a foundational representation interface for unified spoken language modeling. The code is available at: https://github.com/bovod-sjtu/HoliTok.

  • 9 authors
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May 27

DA-VAE: Plug-in Latent Compression for Diffusion via Detail Alignment

Reducing token count is crucial for efficient training and inference of latent diffusion models, especially at high resolution. A common strategy is to build high-compression image tokenizers with more channels per token. However, when trained only for reconstruction, high-dimensional latent spaces often lose meaningful structure, making diffusion training harder. Existing methods address this with extra objectives such as semantic alignment or selective dropout, but usually require costly diffusion retraining. Pretrained diffusion models, however, already exhibit a structured, lower-dimensional latent space; thus, a simpler idea is to expand the latent dimensionality while preserving this structure. We therefore propose Detail-Aligned VAE, which increases the compression ratio of a pretrained VAE with only lightweight adaptation of the pretrained diffusion backbone. DA-VAE uses an explicit latent layout: the first C channels come directly from the pretrained VAE at a base resolution, while an additional D channels encode higher-resolution details. A simple detail-alignment mechanism encourages the expanded latent space to retain the structure of the original one. With a warm-start fine-tuning strategy, our method enables 1024 times 1024 image generation with Stable Diffusion 3.5 using only 32 times 32 tokens, 4times fewer than the original model, within 5 H100-days. It further unlocks 2048 times 2048 generation with SD3.5, achieving a 6times speedup while preserving image quality. We also validate the method and its design choices quantitatively on ImageNet.

  • 4 authors
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Mar 22

Generalized Domain Conditioned Adaptation Network

Domain Adaptation (DA) attempts to transfer knowledge learned in the labeled source domain to the unlabeled but related target domain without requiring large amounts of target supervision. Recent advances in DA mainly proceed by aligning the source and target distributions. Despite the significant success, the adaptation performance still degrades accordingly when the source and target domains encounter a large distribution discrepancy. We consider this limitation may attribute to the insufficient exploration of domain-specialized features because most studies merely concentrate on domain-general feature learning in task-specific layers and integrate totally-shared convolutional networks (convnets) to generate common features for both domains. In this paper, we relax the completely-shared convnets assumption adopted by previous DA methods and propose Domain Conditioned Adaptation Network (DCAN), which introduces domain conditioned channel attention module with a multi-path structure to separately excite channel activation for each domain. Such a partially-shared convnets module allows domain-specialized features in low-level to be explored appropriately. Further, given the knowledge transferability varying along with convolutional layers, we develop Generalized Domain Conditioned Adaptation Network (GDCAN) to automatically determine whether domain channel activations should be separately modeled in each attention module. Afterward, the critical domain-specialized knowledge could be adaptively extracted according to the domain statistic gaps. As far as we know, this is the first work to explore the domain-wise convolutional channel activations separately for deep DA networks. Additionally, to effectively match high-level feature distributions across domains, we consider deploying feature adaptation blocks after task-specific layers, which can explicitly mitigate the domain discrepancy.

  • 6 authors
·
Mar 23, 2021

Few-shot Hybrid Domain Adaptation of Image Generators

Can a pre-trained generator be adapted to the hybrid of multiple target domains and generate images with integrated attributes of them? In this work, we introduce a new task -- Few-shot Hybrid Domain Adaptation (HDA). Given a source generator and several target domains, HDA aims to acquire an adapted generator that preserves the integrated attributes of all target domains, without overriding the source domain's characteristics. Compared with Domain Adaptation (DA), HDA offers greater flexibility and versatility to adapt generators to more composite and expansive domains. Simultaneously, HDA also presents more challenges than DA as we have access only to images from individual target domains and lack authentic images from the hybrid domain. To address this issue, we introduce a discriminator-free framework that directly encodes different domains' images into well-separable subspaces. To achieve HDA, we propose a novel directional subspace loss comprised of a distance loss and a direction loss. Concretely, the distance loss blends the attributes of all target domains by reducing the distances from generated images to all target subspaces. The direction loss preserves the characteristics from the source domain by guiding the adaptation along the perpendicular to subspaces. Experiments show that our method can obtain numerous domain-specific attributes in a single adapted generator, which surpasses the baseline methods in semantic similarity, image fidelity, and cross-domain consistency.

  • 10 authors
·
Oct 30, 2023

Magic 1-For-1: Generating One Minute Video Clips within One Minute

In this technical report, we present Magic 1-For-1 (Magic141), an efficient video generation model with optimized memory consumption and inference latency. The key idea is simple: factorize the text-to-video generation task into two separate easier tasks for diffusion step distillation, namely text-to-image generation and image-to-video generation. We verify that with the same optimization algorithm, the image-to-video task is indeed easier to converge over the text-to-video task. We also explore a bag of optimization tricks to reduce the computational cost of training the image-to-video (I2V) models from three aspects: 1) model convergence speedup by using a multi-modal prior condition injection; 2) inference latency speed up by applying an adversarial step distillation, and 3) inference memory cost optimization with parameter sparsification. With those techniques, we are able to generate 5-second video clips within 3 seconds. By applying a test time sliding window, we are able to generate a minute-long video within one minute with significantly improved visual quality and motion dynamics, spending less than 1 second for generating 1 second video clips on average. We conduct a series of preliminary explorations to find out the optimal tradeoff between computational cost and video quality during diffusion step distillation and hope this could be a good foundation model for open-source explorations. The code and the model weights are available at https://github.com/DA-Group-PKU/Magic-1-For-1.

  • 10 authors
·
Feb 11, 2025 5

DA-DPO: Cost-efficient Difficulty-aware Preference Optimization for Reducing MLLM Hallucinations

Direct Preference Optimization (DPO) has shown strong potential for mitigating hallucinations in Multimodal Large Language Models (MLLMs). However, existing multimodal DPO approaches often suffer from overfitting due to the difficulty imbalance in preference data. Our analysis shows that MLLMs tend to overemphasize easily distinguishable preference pairs, which hinders fine-grained hallucination suppression and degrades overall performance. To address this issue, we propose Difficulty-Aware Direct Preference Optimization (DA-DPO), a cost-effective framework designed to balance the learning process. DA-DPO consists of two main components: (1) Difficulty Estimation leverages pre-trained vision--language models with complementary generative and contrastive objectives, whose outputs are integrated via a distribution-aware voting strategy to produce robust difficulty scores without additional training; and (2) Difficulty-Aware Training reweights preference pairs based on their estimated difficulty, down-weighting easy samples while emphasizing harder ones to alleviate overfitting. This framework enables more effective preference optimization by prioritizing challenging examples, without requiring new data or extra fine-tuning stages. Extensive experiments demonstrate that DA-DPO consistently improves multimodal preference optimization, yielding stronger robustness to hallucinations and better generalization across standard benchmarks, while remaining computationally efficient. The project page is available at https://artanic30.github.io/project_pages/DA-DPO/.

  • 5 authors
·
Jan 2

SeaS: Few-shot Industrial Anomaly Image Generation with Separation and Sharing Fine-tuning

We introduce SeaS, a unified industrial generative model for automatically creating diverse anomalies, authentic normal products, and precise anomaly masks. While extensive research exists, most efforts either focus on specific tasks, i.e., anomalies or normal products only, or require separate models for each anomaly type. Consequently, prior methods either offer limited generative capability or depend on a vast array of anomaly-specific models. We demonstrate that U-Net's differentiated learning ability captures the distinct visual traits of slightly-varied normal products and diverse anomalies, enabling us to construct a unified model for all tasks. Specifically, we first introduce an Unbalanced Abnormal (UA) Text Prompt, comprising one normal token and multiple anomaly tokens. More importantly, our Decoupled Anomaly Alignment (DA) loss decouples anomaly attributes and binds them to distinct anomaly tokens of UA, enabling SeaS to create unseen anomalies by recombining these attributes. Furthermore, our Normal-image Alignment (NA) loss aligns the normal token to normal patterns, making generated normal products globally consistent and locally varied. Finally, SeaS produces accurate anomaly masks by fusing discriminative U-Net features with high-resolution VAE features. SeaS sets a new benchmark for industrial generation, significantly enhancing downstream applications, with average improvements of +8.66% pixel-level AP for synthesis-based AD approaches, +1.10% image-level AP for unsupervised AD methods, and +12.79% IoU for supervised segmentation models. Code is available at https://github.com/HUST-SLOW/SeaS{https://github.com/HUST-SLOW/SeaS}.

  • 6 authors
·
Oct 19, 2024

PA&DA: Jointly Sampling PAth and DAta for Consistent NAS

Based on the weight-sharing mechanism, one-shot NAS methods train a supernet and then inherit the pre-trained weights to evaluate sub-models, largely reducing the search cost. However, several works have pointed out that the shared weights suffer from different gradient descent directions during training. And we further find that large gradient variance occurs during supernet training, which degrades the supernet ranking consistency. To mitigate this issue, we propose to explicitly minimize the gradient variance of the supernet training by jointly optimizing the sampling distributions of PAth and DAta (PA&DA). We theoretically derive the relationship between the gradient variance and the sampling distributions, and reveal that the optimal sampling probability is proportional to the normalized gradient norm of path and training data. Hence, we use the normalized gradient norm as the importance indicator for path and training data, and adopt an importance sampling strategy for the supernet training. Our method only requires negligible computation cost for optimizing the sampling distributions of path and data, but achieves lower gradient variance during supernet training and better generalization performance for the supernet, resulting in a more consistent NAS. We conduct comprehensive comparisons with other improved approaches in various search spaces. Results show that our method surpasses others with more reliable ranking performance and higher accuracy of searched architectures, showing the effectiveness of our method. Code is available at https://github.com/ShunLu91/PA-DA.

  • 7 authors
·
Feb 28, 2023

FLUX3D: High-Fidelity 3D Gaussian Generation with Diffusion-Aligned Sparse Representation

Sparse voxel representation has emerged as a scalable foundation for image-to-3D Gaussian Splatting (3DGS) generation, yet current methods struggle to preserve high-frequency visual details of input images due to two structural bottlenecks. First, they adopt discriminative 2D features optimized for semantic abstraction to construct sparse voxel latents, which suppress reconstructive cues and induce a representation bottleneck. Second, in the generation stage, standard diffusion transformers lack effective mechanisms to align dense 2D image tokens with sparse 3D voxel latents, resulting in a cross-modal correspondence bottleneck. To address these issues, we propose FLUX3D, a scalable image-to-3DGS framework that boosts both representation learning and cross-modal alignment during generation. We first revisit 2D feature selection for sparse-voxel-based 3D representation learning, propose Diffusion-Aligned Structured Latents (DA-SLAT) and couple it with a decoder-only architecture to improve 3DGS reconstruction fidelity. We also design a sparse-structure-aware diffusion framework, which integrates the Sparse-structure Multimodal Diffusion Transformer (SMDiT) and Modal-Aware Rotary Positional Embedding (MARoPE) to achieve geometry-agnostic 2D-3D alignment. Extensive benchmark experiments demonstrate that FLUX3D yields substantial improvements in appearance fidelity and significantly outperforms all state-of-the-art (SOTA) methods in generating high-quality 3DGS assets.

ByteDance ByteDance
·
Jun 22

Answering Unseen Questions With Smaller Language Models Using Rationale Generation and Dense Retrieval

When provided with sufficient explanatory context, smaller Language Models have been shown to exhibit strong reasoning ability on challenging short-answer question-answering tasks where the questions are unseen in training. We evaluate two methods for further improvement in this setting. Both methods focus on combining rationales generated by a larger Language Model with longer contexts created from a multi-hop dense retrieval system. The first method (RR) involves training a Rationale Ranking model to score both generated rationales and retrieved contexts with respect to relevance and truthfulness. We then use the scores to derive combined contexts from both knowledge sources using a number of combinatory strategies. For the second method (RATD) we utilise retrieval-augmented training datasets developed by Hartill et al. 2023 to train a smaller Reasoning model such that it becomes proficient at utilising relevant information from longer text sequences that may be only partially evidential and frequently contain many irrelevant sentences. We find that both methods significantly improve results. Our single best Reasoning model materially improves upon strong comparable prior baselines for unseen evaluation datasets (StrategyQA 58.9 rightarrow 61.7 acc., CommonsenseQA 63.6 rightarrow 72.7 acc., ARC-DA 31.6 rightarrow 52.1 F1, IIRC 25.5 rightarrow 27.3 F1) and a version utilising our prior knowledge of each type of question in selecting a context combination strategy does even better. Our proposed models also generally outperform direct prompts against much larger models (BLOOM 175B and StableVicuna 13B) in both few-shot chain-of-thought and standard few-shot settings.

  • 4 authors
·
Aug 9, 2023

Pearl: A Foundation Model for Placing Every Atom in the Right Location

Accurately predicting the three-dimensional structures of protein-ligand complexes remains a fundamental challenge in computational drug discovery that limits the pace and success of therapeutic design. Deep learning methods have recently shown strong potential as structural prediction tools, achieving promising accuracy across diverse biomolecular systems. However, their performance and utility are constrained by scarce experimental data, inefficient architectures, physically invalid poses, and the limited ability to exploit auxiliary information available at inference. To address these issues, we introduce Pearl (Placing Every Atom in the Right Location), a foundation model for protein-ligand cofolding at scale. Pearl addresses these challenges with three key innovations: (1) training recipes that include large-scale synthetic data to overcome data scarcity; (2) architectures that incorporate an SO(3)-equivariant diffusion module to inherently respect 3D rotational symmetries, improving generalization and sample efficiency, and (3) controllable inference, including a generalized multi-chain templating system supporting both protein and non-polymeric components as well as dual unconditional/conditional modes. Pearl establishes a new state-of-the-art performance in protein-ligand cofolding. On the key metric of generating accurate (RMSD < 2 Å) and physically valid poses, Pearl surpasses AlphaFold 3 and other open source baselines on the public Runs N' Poses and PoseBusters benchmarks, delivering 14.5% and 14.2% improvements, respectively, over the next best model. In the pocket-conditional cofolding regime, Pearl delivers 3.6times improvement on a proprietary set of challenging, real-world drug targets at the more rigorous RMSD < 1 Å threshold. Finally, we demonstrate that model performance correlates directly with synthetic dataset size used in training.

  • 40 authors
·
Oct 28, 2025

Euclid. II. The VIS Instrument

This paper presents the specification, design, and development of the Visible Camera (VIS) on the ESA Euclid mission. VIS is a large optical-band imager with a field of view of 0.54 deg^2 sampled at 0.1" with an array of 609 Megapixels and spatial resolution of 0.18". It will be used to survey approximately 14,000 deg^2 of extragalactic sky to measure the distortion of galaxies in the redshift range z=0.1-1.5 resulting from weak gravitational lensing, one of the two principal cosmology probes of Euclid. With photometric redshifts, the distribution of dark matter can be mapped in three dimensions, and, from how this has changed with look-back time, the nature of dark energy and theories of gravity can be constrained. The entire VIS focal plane will be transmitted to provide the largest images of the Universe from space to date, reaching m_AB>24.5 with S/N >10 in a single broad I_E~(r+i+z) band over a six year survey. The particularly challenging aspects of the instrument are the control and calibration of observational biases, which lead to stringent performance requirements and calibration regimes. With its combination of spatial resolution, calibration knowledge, depth, and area covering most of the extra-Galactic sky, VIS will also provide a legacy data set for many other fields. This paper discusses the rationale behind the VIS concept and describes the instrument design and development before reporting the pre-launch performance derived from ground calibrations and brief results from the in-orbit commissioning. VIS should reach fainter than m_AB=25 with S/N>10 for galaxies of full-width half-maximum of 0.3" in a 1.3" diameter aperture over the Wide Survey, and m_AB>26.4 for a Deep Survey that will cover more than 50 deg^2. The paper also describes how VIS works with the other Euclid components of survey, telescope, and science data processing to extract the cosmological information.

  • 435 authors
·
May 22, 2024

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratio in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially-resolved spectroscopy for thousands of nearby galaxies (median redshift of z = 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between redshifts z = 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGN and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5-meter Sloan Foundation Telescope at Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5-meter du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in July 2016.

  • 353 authors
·
Feb 28, 2017